SCHEMBL15599223

SCHEMBL15599223

Cc1cnc(OC(C)(C)C)c(Cl)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 1/20 0.40
SSTR4 P31391 1/20 0.40
GAA P10253 1/20 0.37
LMNA P02545 1/20 0.35
CYP2C9 P11712 1/20 0.35
TSHR P16473 1/20 0.35
APEX1 P27695 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
DRD1 P21728 1/20 0.34
CCR1 P32246 1/20 0.32
CCR5 P51681 1/20 0.32
CCR8 P51685 1/20 0.32
NOS3 P29474 1/20 0.32
NOS1 P29475 1/20 0.32
NOS2 P35228 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C19 P33261 1/20 0.32
AAK1 Q2M2I8 2/20 0.32
MKNK1 Q9BUB5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17248017 0.80 NOS3 (0.43) SCN9ASSTR4GAASMN1; SMN2CCR1
SCHEMBL16175217 0.79 SCN9A (0.42) SCN9AGAALMNACYP2C9TSHR
SCHEMBL15599218 0.79 SSTR4 (0.47) SSTR4SMN1; SMN2CYP1A2CYP3A4CYP2C19
SCHEMBL18400155 0.78 PTGS2 (0.36) SCN9AGAALMNACYP2C9TSHR
SCHEMBL29458513 0.78 CYP2C9 (0.42) SCN9ASSTR4LMNACYP2C9TSHR
SCHEMBL5942263 0.78 CYP2C9 (0.42) SCN9ASSTR4LMNACYP2C9TSHR
SCHEMBL14032969 0.77 CYP1A2 (0.55) LMNASMN1; SMN2CYP1A2CYP3A4CYP2C19
SCHEMBL15599199 0.77 SCN9A (0.36) SCN9AGAALMNACYP2C9TSHR
SCHEMBL15599221 0.75 PTGS2 (0.51) SSTR4AAK1PTGS2NUDT1
SCHEMBL9509486 0.75 SCN9A (0.37) SCN9ASSTR4GAALMNACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014153037-A1 SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2014-09-25 WO disclosed
WO-2014144545-A2 SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2014-09-18 WO disclosed
WO-2014008458-A2 N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2014-01-09 WO disclosed