Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4526253 | 0.81 | CYP1A2 (0.67) | CYP1A2CYP2C9HIF1AALDH1A1SMN1; SMN2 | |
| SCHEMBL25412903 | 0.78 | CYP1A2 (0.64) | CYP1A2CYP2C9HIF1AALDH1A1SMN1; SMN2 | |
| SCHEMBL27344097 | 0.77 | CYP1A2 (0.62) | CYP1A2CYP2C9HIF1AALDH1A1SMN1; SMN2 | |
| SCHEMBL9195893 | 0.77 | PTPRA (0.64) | CYP1A2CYP2C9HIF1AALDH1A1SMN1; SMN2 | |
| SCHEMBL9043569 | 0.76 | CYP1A2 (0.61) | CYP1A2CYP2C9HIF1AALDH1A1SMN1; SMN2 | |
| SCHEMBL29903072 | 0.75 | CYP1A2 (0.60) | CYP1A2CYP2C9HIF1AALDH1A1SMN1; SMN2 | |
| SCHEMBL27423048 | 0.73 | CYP1A2 (0.58) | CYP1A2CYP2C9HIF1AALDH1A1SMN1; SMN2 | |
| SCHEMBL20703028 | 0.72 | CYP1A2 (0.56) | CYP1A2CYP2C9HIF1AALDH1A1SMN1; SMN2 | |
| SCHEMBL15508293 | 0.72 | PDE10A (0.62) | CYP1A2CYP2C9HIF1ASMN1; SMN2KDM4E | |
| SCHEMBL724711 | 0.72 | ALDH1A1 (0.62) | CYP1A2CYP2C9HIF1AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148401-A1 | Compounds and Methods of Use Thereof for Treating Tumors | GEORGETOWN UNIVERSITY | 2018-05-31 | — | — | US | disclosed |
| US-20180148401-A1 | Compounds and Methods of Use Thereof for Treating Tumors | GEORGETOWN UNIVERSITY | 2018-05-31 | — | — | US | disclosed |
| US-9695108-B2 | Compounds and methods of use thereof for treating tumors | GEORGETOWN UNIVERSITY (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695108-B2 | Compounds and methods of use thereof for treating tumors | GEORGETOWN UNIVERSITY (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150344440-A1 | Compounds and Methods of Use Thereof for Treating Tumors | GEORGETOWN UNIVERSITY | 2015-12-03 | — | — | US | disclosed |
| US-20150344440-A1 | Compounds and Methods of Use Thereof for Treating Tumors | GEORGETOWN UNIVERSITY | 2015-12-03 | — | — | US | disclosed |
| WO-2014032019-A2 | COMPOUNDS AND METHODS OF USE THEREOF FOR TREATING TUMORS | GEORGETOWN UNIVERSITY (US) | 2014-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344440-A1 | Compounds and Methods of Use Thereof for Treating Tumors | VHL, TP53, RHOA | CYP1A2 4173/4885CYP2C9 4206/4885HIF1A 1029/4885 |
| US-20180148401-A1 | Compounds and Methods of Use Thereof for Treating Tumors | VHL, TP53, RHOA | CYP1A2 4173/4885CYP2C9 4206/4885HIF1A 1029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.