Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5456915 | 0.87 | SYK (0.46) | SYKIRAK4CYP17A1ATRACVR1B | |
| SCHEMBL7416577 | 0.85 | LCK (0.45) | LCKATRGSK3BDYRK1AMAPKAPK2 | |
| SCHEMBL30850163 | 0.84 | ATR (0.39) | SYKLCKCYP17A1ATRGSK3B | |
| SCHEMBL2960307 | 0.84 | AAK1 (0.43) | SYKLCKCYP17A1HDAC6ATR | |
| SCHEMBL17282546 | 0.84 | SYK (0.42) | SYKCYP17A1HDAC6ATRACVR1B | |
| SCHEMBL23167942 | 0.83 | HDAC6 (0.56) | SYKHDAC6 | |
| SCHEMBL25138307 | 0.82 | ATR (0.42) | SYKLCKCYP17A1HDAC6ATR | |
| SCHEMBL7412985 | 0.79 | SYK (0.42) | SYKLCKCYP17A1ATRGSK3B | |
| SCHEMBL17017349 | 0.78 | HCRTR1 (0.43) | SYKHDAC6 | |
| SCHEMBL28490153 | 0.76 | SYK (0.40) | SYKCYP17A1ATRACVR1BTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014006554-A1 | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-01-09 | — | — | WO | disclosed |