Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5456915 | 0.85 | SYK (0.46) | AAK1SYKCYP17A1RORCATR | |
| SCHEMBL15599330 | 0.84 | SYK (0.42) | SYKLCKCYP17A1HDAC6RORC | |
| SCHEMBL17202399 | 0.84 | AAK1 (0.43) | AAK1SYKLCKCYP17A1NPC1 | |
| SCHEMBL29360815 | 0.84 | AAK1 (0.43) | AAK1SYKLCKCYP17A1NPC1 | |
| SCHEMBL1181471 | 0.84 | AAK1 (0.51) | AAK1LCKNPC1ALDH1A1RORC | |
| SCHEMBL15660587 | 0.83 | AAK1 (0.41) | AAK1SYKLCKNPC1RORC | |
| SCHEMBL17282546 | 0.83 | SYK (0.42) | SYKCYP17A1HDAC6RORCATR | |
| SCHEMBL858165 | 0.83 | AAK1 (0.42) | AAK1LCKNPC1RORCRECQL | |
| SCHEMBL23167942 | 0.82 | HDAC6 (0.56) | SYKHDAC6 | |
| SCHEMBL15599368 | 0.82 | AAK1 (0.44) | AAK1LCKNPC1ALDH1A1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132201-B1 | NOVEL 2-HETEROARYL SUBSTITUTED BENZOTHIOPHENES AND BENZOFURANES | ASTRAZENECA AB (SE) | 2016-11-16 | — | — | EP | disclosed |
| EP-2132201-B1 | NOVEL 2-HETEROARYL SUBSTITUTED BENZOTHIOPHENES AND BENZOFURANES | ASTRAZENECA AB (SE) | 2016-11-16 | — | — | EP | disclosed |
| US-7772256-B2 | 2-heteroaryl substituted benzothiophenes and benzofuranes 709 | ASTRAZENECA AB (SE) | 2010-08-10 | — | — | US | disclosed |
| US-7772256-B2 | 2-heteroaryl substituted benzothiophenes and benzofuranes 709 | ASTRAZENECA AB (SE) | 2010-08-10 | — | — | US | disclosed |
| EP-2132201-A1 | NOVEL 2-HETEROARYL SUBSTITUTED BENZOTHIOPHENES AND BENZOFURANES 709 | AstraZeneca AB (SE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008108730-A1 | NOVEL 2-HETEROARYL SUBSTITUTED BENZOTHIOPHENES AND BENZOFURANES 709 | ASTRAZENECA AB (SE) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008108730-A1 | NOVEL 2-HETEROARYL SUBSTITUTED BENZOTHIOPHENES AND BENZOFURANES 709 | ASTRAZENECA AB (SE) | 2008-09-12 | — | — | WO | disclosed |
| US-20080221149-A1 | 2-[6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol; for imaging amyloid deposits in living patients | ASTRAZENECA AB (SE) | 2008-09-11 | — | — | US | disclosed |
| US-20080221149-A1 | 2-[6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol; for imaging amyloid deposits in living patients | ASTRAZENECA AB (SE) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221149-A1 | 2-[6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol; for imaging amyloid deposits in living patients | PSEN1, APP, PSEN2 | AAK1 2251/4885SYK 1060/4885LCK 3263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.