SCHEMBL156116

SCHEMBL156116

NC(=O)c1c(O)cc(O)c([N+](=O)[O-])c1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
POLB P06746 1/20 0.46
CTDSP1 Q9GZU7 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
TSHR P16473 2/20 0.41
CYP3A4 P08684 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CA1 P00915 3/20 0.40
CA2 P00918 3/20 0.40
CA12 O43570 2/20 0.38
CA9 Q16790 2/20 0.38
LMNA P02545 1/20 0.38
GAA P10253 1/20 0.38
ERN1 O75460 1/20 0.37
GPR35 Q9HC97 2/20 0.36
S100A4 P26447 1/20 0.36
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
TTR P02766 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9617118 0.85 CA1 (0.51) KDM4ETDP1L3MBTL1CYP3A4SMN1; SMN2
SCHEMBL28777971 0.81 GPR35 (0.45) KDM4ETDP1TSHRSMN1; SMN2CA1
SCHEMBL3239188 0.73 TSHR (0.46) KDM4ETDP1POLBCTDSP1L3MBTL1
SCHEMBL6363208 0.72 GPR35 (0.48) KDM4ETDP1POLBCTDSP1L3MBTL1
SCHEMBL31514658 0.72 CA1 (0.46) KDM4ETDP1CYP3A4CA1CA2
SCHEMBL5660720 0.72 CYP3A4 (0.41) KDM4ETDP1POLBCTDSP1L3MBTL1
SCHEMBL9617124 0.71 SMN1; SMN2 (0.42) POLBTSHRSMN1; SMN2LMNAGAA
SCHEMBL11441634 0.69 GPR35 (0.48) KDM4ETDP1TSHRCYP3A4SMN1; SMN2
SCHEMBL28134615 0.69 GPR35 (0.36) KDM4ETDP1CYP3A4CA1CA2
SCHEMBL31221855 0.68 GPR35 (0.47) KDM4ETDP1TSHRCYP3A4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 629 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9182408-B2 Method of screening by using conformation sensitive peptides VALNEVA (FR) 2015-11-10 US claimed
EP-1789799-B2 METHOD OF SCREENING BY USING CONFORMATION SENSITIVE PEPTIDES VALNEVA (FR) 2015-03-11 EP claimed
EP-1789799-B1 METHOD OF SCREENING BY USING CONFORMATION SENSITIVE PEPTIDES VIVALIS (FR) 2011-11-09 EP claimed
US-20080076669-A1 Method of screening by using conformation sensitive peptides VALNEVA (FR) 2008-03-27 US claimed
EP-1789799-A2 METHOD OF SCREENING BY USING CONFORMATION SENSITIVE PEPTIDES Vivalis (FR) 2007-05-30 EP claimed
WO-2006046134-A2 METHOD OF SCREENING BY USING CONFORMATION SENSITIVE PEPTIDES VIVALIS (FR) 2006-05-04 WO claimed
EP-1637885-A1 Method of screening by using conformation sensitive peptides Vivalis (FR) 2006-03-22 EP claimed
JP-1228949-A None JP disclosed
JP-3095141-A None JP disclosed
US-12383558-B2 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections EMORY UNIVERSITY (US) 2025-08-12 US disclosed
EP-4556010-A2 JAK INHIBITORS FOR USE IN THE PREVENTION OR TREATMENT OF A VIRAL DISEASE CAUSED BY A CORONAVIRIDAE Emory University (US) 2025-05-21 EP disclosed
EP-4032897-B1 MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES GILEAD PHARMASSET LLC (US) 2025-01-29 EP disclosed
EP-2970357-B1 AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV IDENIX PHARMACEUTICALS LLC (US) 2025-01-01 EP disclosed
US-20030050229-A1 Methods and compositions for treating hepatitis C virus IDENIX PHARMACEUTICALS LLC 2003-03-13 US disclosed
WO-2002048165-A2 ANTIVIRAL AGENTS FOR TREATMENT OF FLAVIVIRIDAE INFECTIONS PHARMASSET LTD. (BB) 2002-06-20 WO disclosed
WO-2002032920-A2 MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION PHARMASSET LIMITED (BB) 2002-04-25 WO disclosed
WO-2001092282-A2 METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUSES AND PESTIVIRUSES IDENIX (CAYMAN) LIMITED (KY) 2001-12-06 WO disclosed
WO-2001090121-A2 METHODS AND COMPOSITIONS FOR TREATING HEPATITIS C VIRUS IDENIX (CAYMAN) LIMITED (KY) 2001-11-29 WO disclosed
JP-H0395141-A NOVEL 3-NITRO-2,4,6-TRIHYDOXYBENZOIC ACID AND DERIVATIVE THEREOF AND PRODUCTION THEREOF JAPAN TOBACCO INC 1991-04-19 JP disclosed
JP-H01228949-A 3-NITRO-2,4,6-TRIHYDROXYBENZAMIDE AND PRODUCTION THEREOF RIKAGAKU KENKYUSHO 1989-09-12 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030050229-A1 Methods and compositions for treating hepatitis C virus HAVCR2, HCCS, SLC10A1 KDM4E 4422/4885TDP1 2361/4885POLB 847/4885
US-12383558-B2 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections JAK1, JAK3, PNP KDM4E 628/4885TDP1 443/4885POLB 165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.