Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27825688 | 0.83 | CDK2 (0.51) | CYP3A4MAPTPMP22COMTALDH1A1 | |
| SCHEMBL28709886 | 0.78 | ALDH1A1 (0.57) | CYP3A4MAPTPMP22ALDH1A1KMT2A | |
| SCHEMBL28412179 | 0.74 | GRIN2D (0.43) | CYP3A4MAPTPMP22BLMCOMT | |
| SCHEMBL6376194 | 0.73 | KDM4E (0.44) | MAPTBLMALDH1A1KMT2ALMNA | |
| SCHEMBL156116 | 0.72 | KDM4E (0.46) | CYP3A4MAPTPMP22ALDH1A1KMT2A | |
| SCHEMBL6207406 | 0.72 | CYP3A4 (0.58) | CYP3A4MAPTPMP22BLMALDH1A1 | |
| SCHEMBL27725375 | 0.72 | ALDH1A1 (0.50) | CYP3A4MAPTPMP22BLMALDH1A1 | |
| SCHEMBL27713898 | 0.72 | COMT (0.57) | COMTALDH1A1 | |
| SCHEMBL27530393 | 0.71 | ALDH1A1 (0.46) | CYP3A4MAPTALDH1A1KMT2ALMNA | |
| SCHEMBL667585 | 0.71 | TSHR (0.54) | CYP3A4MAPTPMP22BLMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017181383-A1 | HEPATITIS C VIRUS INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-10-26 | — | — | WO | disclosed |
| CN-101336247-B | Antiviral nucleosides | HOFFMANN LA ROCHE | 2013-01-23 | — | — | CN | disclosed |
| CN-102424698-A | Modified 2' and 3' -nucleoside produgs for treating flaviridae infections | CENTRE NAT RECH SCIENT (FR) | 2012-04-25 | — | — | CN | disclosed |
| CN-101663284-A | Macrocyclic compounds as hcv ns3 protease inhibitors | NOVARTIS AG | 2010-03-03 | — | — | CN | disclosed |
| CN-101541826-A | Macrocyclic HCV inhibitors and their uses | NOVARTIS AG (CH) | 2009-09-23 | — | — | CN | disclosed |
| CN-101469009-A | Methods and compositions for treating hepatitis c virus | IDENIX CAYMAN LTD (KY) | 2009-07-01 | — | — | CN | disclosed |
| CN-101466728-A | HCV inhibitors comprising beta amino acids and their uses | NOVARTIS AG (CH) | 2009-06-24 | — | — | CN | disclosed |
| CN-101367856-A | Methods and compositions for treating hepatitis c virus | IDENIX CAYMAN LTD (KY) | 2009-02-18 | — | — | CN | disclosed |
| CN-100402545-C | Methods and compositions for treating hepatitis c virus | IDENNIKOS KY CO LTD (VG) | 2008-07-16 | — | — | CN | disclosed |
| CN-101115725-A | 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation | UNIV EMORY (US) | 2008-01-30 | — | — | CN | disclosed |
| EP-1438054-A4 | METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUSES AND PESTIVIRUSES USING 4'-MODIFIED NUCLEOSIDE | IDENIX CAYMAN LTD (KY) | 2006-07-26 | — | — | EP | disclosed |
| EP-1438054-A1 | METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUSES AND PESTIVIRUSES USING 4'-MODIFIED NUCLEOSIDE | Idenix (Cayman) Limited (KY) | 2004-07-21 | — | — | EP | disclosed |
| CN-1443191-A | Methods and compositions for treating hepatitis c virus | IDENNIKOS KY CO LTD (KY) | 2003-09-17 | — | — | CN | disclosed |
| WO-2003026675-A1 | METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUSES AND PESTIVIRUSES USING 4'-MODIFIED NUCLEOSIDE | IDENIX (CAYMAN) LIMITED (KY) | 2003-04-03 | — | — | WO | disclosed |