Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.81 |
| ▸ | MAPT | P10636 | 10/20 | 0.81 |
| ▸ | HPGD | P15428 | 9/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.81 |
| ▸ | DUSP3 | P51452 | 8/20 | 0.81 |
| ▸ | TP53 | P04637 | 8/20 | 0.81 |
| ▸ | POLB | P06746 | 5/20 | 0.81 |
| ▸ | HTT | P42858 | 4/20 | 0.81 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.81 |
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | BLM | P54132 | 1/20 | 0.81 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.81 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.81 |
| ▸ | MEN1 | O00255 | 9/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.78 |
| ▸ | LMNA | P02545 | 7/20 | 0.78 |
| ▸ | ESR1 | P03372 | 1/20 | 0.78 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15575996 | 0.90 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL30065644 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL15575443 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL15617120 | 0.87 | DUSP3 (0.78) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL29921361 | 0.87 | ALDH1A1 (0.98) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL15617087 | 0.86 | ALDH1A1 (0.85) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL15617100 | 0.86 | ALDH1A1 (0.84) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL15617156 | 0.85 | ALDH1A1 (0.79) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL15617091 | 0.85 | ALDH1A1 (0.82) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL20660703 | 0.85 | ALDH1A1 (0.82) | ALDH1A1KDM4EMAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2890379-B1 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2019-04-03 | — | — | EP | disclosed |
| US-20180127407-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2018-05-10 | — | — | US | disclosed |
| US-9845320-B2 | Benzothiazole or benzoxazole compounds as sumo activators | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2017-12-19 | — | — | US | disclosed |
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | ICAHN SCHOOL MED MOUNT SINAI (US) | 2015-08-06 | — | — | US | disclosed |
| WO-2014036242-A2 | BENZOTHIAZOLE OR BENZOXAZOLE COMPOUNDS AS SUMO ACTIVATORS | MOUNT SINAI SCHOOL OF MEDICINE (US) | 2014-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218148-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | SUMO2, UBA2, SUMO1 | ALDH1A1 3054/4885KDM4E 1851/4885MAPT 1545/4885 |
| US-20180127407-A1 | Benzothiazole Or Benzoxazole Compounds As Sumo Activators | SUMO2, UBA2, SUMO1 | ALDH1A1 3054/4885KDM4E 1851/4885MAPT 1545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.