SCHEMBL156192

SCHEMBL156192

[c]1ncc2ccncc2n1

nearest known ligand 0.31

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAP4K4 O95819 1/20 0.31
MINK1 Q8N4C8 1/20 0.31
TNIK Q9UKE5 1/20 0.31
CSNK1D P48730 1/20 0.31
CSNK1E P49674 1/20 0.31
CLK1 P49759 1/20 0.31
DYRK1A Q13627 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL158440 0.83 KDM4E (0.32) CSNK1DCSNK1ECLK1DYRK1A
SCHEMBL3032 0.73 ALDH1A1 (0.44)
SCHEMBL3943498 0.70
SCHEMBL16316 0.70 MAP4K4 (0.34) MAP4K4MINK1TNIKCSNK1DCSNK1E
SCHEMBL3936849 0.68 MAP4K4 (0.30) MAP4K4MINK1TNIKCSNK1DCSNK1E
SCHEMBL406493 0.67 BACE1 (0.42) DYRK1A
SCHEMBL2303882 0.67 CYP1A2 (0.45)
SCHEMBL407628 0.67 NR4A2 (0.41) DYRK1A
SCHEMBL406789 0.67 BACE1 (0.41)
SCHEMBL19307656 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3513 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024106781-A1 LIPID COMPOUND AND COMPOSITION FOR DELIVERY OF ACTIVE SUBSTANCE 한국생명공학연구원 2024-05-23 WO claimed
US-20230382905-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY EVOTEC INTERNATIONAL GMBH (DE) 2023-11-30 US claimed
EP-3901147-B1 ACYLAMINO BRIDGED HETEROCYCLIC COMPOUND, AND COMPOSITION AND APPLICATION THEREOF BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) 2023-11-22 EP claimed
US-20230357268-A1 PREPARATION AND APPLICATION OF TRICYCLIC PYRIMIDINONE COMPOUND AND ITS COMPOSITION NEUSCO BIOTECH LIMITED (CN) 2023-11-09 US claimed
US-20230271980-A1 PREPARATION AND APPLICATION OF TRICYCLIC PYRIMIDINONE COMPOUND AND ITS COMPOSITION NEUSCO BIOTECH LIMITED (CN) 2023-08-31 US claimed
EP-4232154-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY Evotec International GmbH (DE) 2023-08-30 EP claimed
US-20230242532-A1 TETRACYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF NEUSCO BIOTECH LIMITED (CN) 2023-08-03 US claimed
US-20230212168-A1 ENDOCYCLIC PYRIMIDINONE COMPOUNDS, AND PREPARATION METHODS, COMPOSITIONS AND USE THEREOF NEUSCO BIOTECH LIMITED (CN) 2023-07-06 US claimed
EP-4180436-A1 TRICYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF Neusco Biotech Limited (CN) 2023-05-17 EP claimed
EP-4174070-A1 TRICYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF Neusco Biotech Limited (CN) 2023-05-03 EP claimed
US-20110306597-A1 Nicotinamide Derivatives CRAWFORTH JAMES MICHAEL (GB) 2011-12-15 US claimed
US-7880002-B2 Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists MILLENNIUM PHARMACEUTICALS, INC. (US) 2011-02-01 US claimed
US-7879856-B2 5-(quinoxalin-2-yl)-N2-(3,4,5-trimethoxyphenyl)thiazole-2,4-diamine; useful in inhibiting the activity of the receptor protein tyrosine kinase Axl; rheumatoid arthritis, vascular disease, vascular injury, psoriasis, visual impairment due to macular degeneration, diabetic retinopathy, retinopathy RIGEL PHARMACEUTICALS, INC. (US) 2011-02-01 US claimed
US-20090105211-A1 INHIBITORS OF HEDGEHOG PATHWAY EXELIXIS, INC. (US) 2009-04-23 US claimed
US-20080227789-A1 DIAMINOTHIAZOLES USEFUL AS AXL INHIBITORS RIGEL PHARMACEUTICALS, INC. (US) 2008-09-18 US claimed
WO-2008080134-A2 4-AMIN0-2- (HETERO) ARYLAMINO-5- (HETERO) ARYLTHIAZOLES USEFUL AS AXL INHIBITORS RIGEL PHARMACEUTICALS, INC. (US) 2008-07-03 WO claimed
US-20060172994-A1 Compounds useful as chemokine receptor antagonists MILLENNIUM PHARMACEUTICALS, INC. 2006-08-03 US claimed
WO-2006071875-A1 COMPOUNDS USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS MILLENNIUM PHARMACEUTICALS, INC. (US) 2006-07-06 WO claimed
US-6784174-B1 INHIBITORS OF THE PRODUCTION OF CYTOKINES SUCH AS TNF ASTRAZENECA AB (SE) 2004-08-31 US claimed
EP-1165566-B1 PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASE ASTRAZENECA AB (SE) 2003-08-20 EP claimed