Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.51 |
| ▸ | TUBB | P07437 | 4/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1563040 | 0.87 | TUBB1 (0.78) | TUBB1MAPTSMN1; SMN2NPSR1TP53 | |
| SCHEMBL29441465 | 0.87 | TUBB1 (1.00) | TUBB1MAPTSMN1; SMN2NPSR1TP53 | |
| SCHEMBL3919311 | 0.87 | TUBB1 (0.81) | TUBB1MAPTSMN1; SMN2NPSR1TP53 | |
| SCHEMBL30356826 | 0.87 | TUBB1 (0.81) | TUBB1MAPTSMN1; SMN2NPSR1TP53 | |
| SCHEMBL565514 | 0.87 | TUBB1 (1.00) | TUBB1MAPTSMN1; SMN2NPSR1TP53 | |
| SCHEMBL14387491 | 0.85 | TUBB1 (0.80) | TUBB1MAPTSMN1; SMN2NPSR1TP53 | |
| SCHEMBL1562918 | 0.84 | TUBB1 (0.77) | TUBB1MAPTSMN1; SMN2NPSR1TP53 | |
| SCHEMBL590922 | 0.83 | MAPT (0.73) | TUBB1MAPTSMN1; SMN2NPSR1NR4A2 | |
| SCHEMBL30075344 | 0.83 | MAPT (0.73) | TUBB1MAPTSMN1; SMN2NPSR1NR4A2 | |
| SCHEMBL12480809 | 0.82 | MAPT (0.71) | TUBB1MAPTSMN1; SMN2NPSR1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506960-B1 | Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis-related disorders | NAT HEALTH RESEARCH INSTITUTES (TW) | 2011-04-06 | — | — | EP | claimed |
| US-20050267108-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-12-01 | — | — | US | claimed |
| EP-1506960-A1 | Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis-related disorders | National Health Research Institutes (TW) | 2005-02-16 | — | — | EP | claimed |
| EP-1506960-B1 | Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis-related disorders | NAT HEALTH RESEARCH INSTITUTES (TW) | 2011-04-06 | — | — | EP | disclosed |
| EP-1506960-B1 | Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis-related disorders | NAT HEALTH RESEARCH INSTITUTES (TW) | 2011-04-06 | — | — | EP | disclosed |
| US-7528165-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-05-05 | — | — | US | disclosed |
| US-7528165-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-05-05 | — | — | US | disclosed |
| US-7528165-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-05-05 | — | — | US | disclosed |
| US-20050267108-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-12-01 | — | — | US | disclosed |
| EP-1506960-A1 | Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis-related disorders | National Health Research Institutes (TW) | 2005-02-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267108-A1 | Indole compounds | TUBB1, TUBB3, TUBB | TUBB1 1/4885MAPT 55/4885SMN1; SMN2 3609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.