Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2142144 | 0.89 | MAPT (0.42) | MAPTLMNAALDH1A1METSMN1; SMN2 | |
| SCHEMBL2143583 | 0.85 | PDK2 (0.40) | MAPTLMNAALDH1A1METSMN1; SMN2 | |
| SCHEMBL2128838 | 0.82 | MAPT (0.43) | MAPTLMNAALDH1A1METSMN1; SMN2 | |
| SCHEMBL2127475 | 0.79 | PDK2 (0.41) | MAPTLMNAALDH1A1METSMN1; SMN2 | |
| SCHEMBL2143368 | 0.79 | PDK2 (0.41) | MAPTLMNAALDH1A1METSMN1; SMN2 | |
| SCHEMBL20242567 | 0.75 | MET (0.47) | MAPTLMNAALDH1A1METSMN1; SMN2 | |
| SCHEMBL14851865 | 0.74 | SMN1; SMN2 (0.48) | MAPTLMNAALDH1A1METSMN1; SMN2 | |
| SCHEMBL1919429 | 0.72 | ENPP2 (0.55) | — | |
| SCHEMBL5573222 | 0.72 | MAPT (0.76) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL24378197 | 0.72 | MAPT (0.61) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424843-B1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2014-03-26 | — | — | EP | disclosed |