Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.45 |
| ▸ | KAT6A | Q92794 | 4/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16442491 | 0.86 | TAS1R3 (0.41) | TAS1R3TAS1R1TAS1R2KAT6AF10 | |
| SCHEMBL16959752 | 0.84 | TAS1R3 (0.48) | TAS1R3TAS1R1TAS1R2KAT6AF10 | |
| SCHEMBL2095723 | 0.83 | KAT6A (0.47) | TAS1R3TAS1R1TAS1R2KAT6AF10 | |
| SCHEMBL27743203 | 0.82 | TAS1R3 (0.50) | TAS1R3TAS1R1TAS1R2KAT6AF10 | |
| SCHEMBL697586 | 0.81 | MAOB (0.55) | TAS1R3TAS1R1TAS1R2KAT6AHDAC8 | |
| SCHEMBL29742938 | 0.81 | MAOB (0.55) | TAS1R3TAS1R1TAS1R2KAT6AHDAC8 | |
| SCHEMBL13444652 | 0.81 | TAS1R3 (0.46) | TAS1R3TAS1R1TAS1R2KAT6AF10 | |
| SCHEMBL17191010 | 0.81 | F10 (0.50) | TAS1R3TAS1R1TAS1R2KAT6AF10 | |
| SCHEMBL2093430 | 0.80 | TAS1R3 (0.46) | TAS1R3TAS1R1TAS1R2KAT6AF10 | |
| SCHEMBL16952519 | 0.80 | TAS1R3 (0.43) | TAS1R3TAS1R1TAS1R2KAT6AF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307425-B1 | IMIDAZOTHIADIAZOLES DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-26 | — | — | EP | disclosed |