Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GPR139 | Q6DWJ6 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10098857 | 0.84 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL1561845 | 0.84 | HPSE (0.53) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL5531874 | 0.83 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL6234424 | 0.83 | HPSE (0.52) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL1562841 | 0.81 | HPSE (0.60) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL17662398 | 0.81 | HDAC3 (0.57) | ALDH1A1SMN1; SMN2NPSR1HPGDTSHR | |
| SCHEMBL18493192 | 0.81 | HPSE (0.50) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL19649562 | 0.80 | HPSE (0.53) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL5651138 | 0.80 | HPSE (0.50) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL25734944 | 0.80 | HPSE (0.50) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575391-B2 | 5-substituted-2-phenylamino benzamides as MEK inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2013-11-05 | — | — | US | disclosed |
| EP-1780197-B9 | 5-SUBSTITUTED-2-PHENYLAMINO BENZAMIDES AS MEK INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2011-04-06 | — | — | EP | disclosed |
| EP-1780197-B1 | 5-SUBSTITUTED-2-PHENYLAMINO BENZAMIDES AS MEK INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2010-10-20 | — | — | EP | disclosed |
| US-20100197676-A1 | 5-Substituted-2-Phenylamino Benzamides as Mek Inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-08-05 | — | — | US | disclosed |
| US-7745663-B2 | 5-Substituted-2-phenylamino benzamides as MEK inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-06-29 | — | — | US | disclosed |
| US-20090233915-A1 | 5-Substituted-2-Phenylamino Benzamides as MEK Inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-09-17 | — | — | US | disclosed |
| EP-1780197-A1 | 5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197676-A1 | 5-Substituted-2-Phenylamino Benzamides as Mek Inhibitors | BRAF, RAF1, NRAS | ALDH1A1 680/4885SMN1; SMN2 2741/4885CYP1A2 942/4885 |
| US-20090233915-A1 | 5-Substituted-2-Phenylamino Benzamides as MEK Inhibitors | BRAF, RAF1, NRAS | ALDH1A1 680/4885SMN1; SMN2 2741/4885CYP1A2 942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.