Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15628122 | 0.87 | MEN1 (0.40) | HTR7CHRM1MEN1KMT2AGAA | |
| SCHEMBL7657174 | 0.86 | GAA (0.42) | CHRM1MEN1KMT2AGAAMAPT | |
| SCHEMBL20580064 | 0.86 | GAA (0.42) | CHRM1MEN1KMT2AGAAMAPT | |
| SCHEMBL7657163 | 0.86 | GAA (0.42) | CHRM1MEN1KMT2AGAAMAPT | |
| Bromide SCHEMBL6178391 | 0.85 | GAA (0.41) | CHRM1MEN1KMT2AGAAMAPT | |
| SCHEMBL15628123 | 0.84 | HTR6 (0.45) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL15628098 | 0.84 | MEN1 (0.38) | MEN1KMT2AGAAMAPTALOX5 | |
| SCHEMBL15628083 | 0.80 | KCNH2 (0.38) | MEN1KMT2AGAAMAPTALOX5 | |
| SCHEMBL20580338 | 0.80 | ALDH1A1 (0.37) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL20580336 | 0.80 | ALDH1A1 (0.37) | MEN1KMT2AGAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897944-B1 | SUBSTITUTED 1,5-BENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2016-10-26 | — | — | EP | disclosed |
| US-9187434-B2 | Substituted 1,5-benzodiazepinones compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150274679-A1 | SUBSTITUTED 1,5-BENZODIAZEPINONES COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2015-10-01 | — | — | US | disclosed |
| WO-2014047369-A1 | SUBSTITUTED 1,5-BENZODIAZEPINONE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274679-A1 | SUBSTITUTED 1,5-BENZODIAZEPINONES COMPOUNDS | CNR1, RXFP3, NPY1R | HTR7 77/4885CHRM1 175/4885MEN1 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.