Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.52 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
| ▸ | CDK2AP1 | O14519 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.43 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554677 | 0.89 | CHEK1 (0.55) | CHEK1CDK2AP1 | |
| SCHEMBL1563534 | 0.88 | CHEK1 (0.68) | USP30CHEK1CDK2AP1 | |
| SCHEMBL1563523 | 0.87 | USP30 (0.63) | USP30CHEK1ACKR3CDK2AP1PARP1 | |
| SCHEMBL27657374 | 0.85 | CHEK1 (0.71) | USP30CHEK1CDK2AP1PARP1 | |
| SCHEMBL1562834 | 0.85 | CHEK1 (0.71) | USP30CHEK1CDK2AP1PARP1 | |
| SCHEMBL1563863 | 0.84 | USP30 (0.53) | USP30CHEK1ACKR3CDK2AP1PARP1 | |
| SCHEMBL1564584 | 0.83 | USP30 (0.64) | USP30CHEK1ACKR3PARP1ANO1 | |
| SCHEMBL1562936 | 0.81 | USP30 (0.55) | USP30CHEK1ACKR3CDK2AP1PARP1 | |
| SCHEMBL5001062 | 0.81 | CHEK1 (0.58) | USP30CHEK1CDK2AP1 | |
| SCHEMBL1563670 | 0.81 | USP30 (0.68) | USP30CHEK1ACKR3PARP1ANO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |