Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.51 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1563670 | 0.97 | USP30 (0.68) | USP30CHEK1ACKR3PARP1PBK | |
| SCHEMBL4212172 | 0.91 | USP30 (0.52) | USP30CHEK1PARP1PBKHDAC4 | |
| SCHEMBL1563534 | 0.89 | CHEK1 (0.68) | USP30CHEK1 | |
| SCHEMBL5554697 | 0.87 | CHEK1 (0.56) | CHEK1ALOX15GAAMAPTGFER | |
| SCHEMBL27657374 | 0.86 | CHEK1 (0.71) | USP30CHEK1PARP1 | |
| SCHEMBL1562834 | 0.86 | CHEK1 (0.71) | USP30CHEK1PARP1 | |
| SCHEMBL1563523 | 0.84 | USP30 (0.63) | USP30CHEK1ACKR3PARP1PBK | |
| SCHEMBL5550850 | 0.84 | CHEK1 (0.59) | USP30CHEK1ALOX15GAAMAPT | |
| SCHEMBL1562875 | 0.83 | USP30 (0.57) | USP30CHEK1ACKR3PARP1PBK | |
| SCHEMBL28763401 | 0.82 | USP30 (0.60) | USP30CHEK1ACKR3PARP1PBK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | CHEK1, CHKA, CHEK2 | USP30 2709/4885CHEK1 1/4885ACKR3 2959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.