Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.54 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 2/20 | 0.53 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1564584 | 0.97 | USP30 (0.64) | USP30CHEK1ACKR3PARP1PBK | |
| SCHEMBL1562834 | 0.89 | CHEK1 (0.71) | USP30CHEK1PARP1 | |
| SCHEMBL27657374 | 0.89 | CHEK1 (0.71) | USP30CHEK1PARP1 | |
| SCHEMBL4212172 | 0.88 | USP30 (0.52) | USP30CHEK1PARP1PBKHDAC4 | |
| SCHEMBL1563523 | 0.87 | USP30 (0.63) | USP30CHEK1ACKR3PARP1PBK | |
| SCHEMBL5550850 | 0.86 | CHEK1 (0.59) | USP30CHEK1ALOX15GAAMAPT | |
| SCHEMBL1563534 | 0.86 | CHEK1 (0.68) | USP30CHEK1 | |
| SCHEMBL28763401 | 0.85 | USP30 (0.60) | USP30CHEK1ACKR3PARP1PBK | |
| SCHEMBL5554697 | 0.84 | CHEK1 (0.56) | CHEK1ALOX15GAAMAPTGFER | |
| SCHEMBL27677393 | 0.84 | CHEK1 (0.54) | USP30CHEK1ALOX15GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |