SCHEMBL1563020

SCHEMBL1563020

CC/C(C)=N/NC(=O)c1cccc2ccccc12

nearest known ligand 0.60

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 7/20 0.60
▸ MEN1 O00255 6/20 0.60
▸ NPC1 O15118 4/20 0.60
▸ RAB9A P51151 4/20 0.60
▸ POLB P06746 1/20 0.60
▸ AGTR1 P30556 1/20 0.60
▸ GAA P10253 1/20 0.56
▸ SMN1; SMN2 Q16637 1/20 0.56
▸ KDM4E B2RXH2 1/20 0.56
▸ PLK1 P53350 1/20 0.55
▸ MMP3 P08254 1/20 0.53
▸ HDAC8 Q9BY41 1/20 0.53
▸ ALDH1A1 P00352 1/20 0.48
▸ HPGD P15428 1/20 0.48
▸ MCL1 Q07820 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1563022 1.00 KMT2A (0.60) KMT2AMEN1NPC1RAB9APOLB
SCHEMBL6636696 1.00 KMT2A (0.60) KMT2AMEN1NPC1RAB9APOLB
SCHEMBL6638592 0.86 SMN1; SMN2 (0.57) KMT2AMEN1NPC1RAB9APOLB
SCHEMBL2276266 0.86 SMN1; SMN2 (0.57) KMT2AMEN1NPC1RAB9APOLB
SCHEMBL29607527 0.86 SMN1; SMN2 (0.57) KMT2AMEN1NPC1RAB9APOLB
SCHEMBL2276263 0.86 SMN1; SMN2 (0.57) KMT2AMEN1NPC1RAB9APOLB
SCHEMBL1563654 0.85 KMT2A (0.56) KMT2AMEN1NPC1RAB9APOLB
SCHEMBL6633882 0.85 KMT2A (0.56) KMT2AMEN1NPC1RAB9APOLB
SCHEMBL1563655 0.85 KMT2A (0.56) KMT2AMEN1NPC1RAB9APOLB
SCHEMBL1561989 0.84 KMT2A (0.66) KMT2AMEN1NPC1RAB9APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9556351-B2 Rubber composition suitable for use as a cap ply in a tire Bridgestone Americas Tire Operations, Inc. (US) 2017-01-31 — — US disclosed
US-20160040024-A1 RUBBER COMPOSITION SUITABLE FOR USE AS A CAP PLY IN A TIRE BRIDGESTONE AMERICAS TIRE OPERATIONS, LLC 2016-02-11 — — US disclosed
US-9163127-B2 Rubber composition suitable for use as a cap ply in a tire BRIDGESTONE AMERICAS TIRE OPERATIONS, LLC (US) 2015-10-20 — — US disclosed
US-20140005320-A1 RUBBER COMPOSITION SUITABLE FOR USE AS A CAP PLY IN A TIRE BRIDGESTONE AMERICAS TIRE OPERATIONS, LLC (US) 2014-01-02 — — US disclosed
EP-1475408-B1 RUBBER COMPOSITION AND PNEUMATIC TIRE MADE THEREFROM BRIDGESTONE CORP (JP) 2011-04-06 — — EP disclosed
EP-1083199-B1 RUBBER COMPOSITION AND PNEUMATIC TIRE BRIDGESTONE CORP (JP) 2006-08-02 — — EP disclosed
US-20050176858-A1 Rubber composition and pneumatic tire made therefrom BRIDGESTONE CORPORATION 2005-08-11 — — US disclosed
EP-1184412-B1 Rubber composition and heavy duty pneumetic tire using the rubber composition BRIDGESTONE CORP (JP) 2005-01-12 — — EP disclosed
US-6822027-B2 MODIFIED STYRENE-BUTADIENE COPOLYMER RUBBER THAT HAS A TIN ATOM, NATURAL RUBBER OR SYNTHETIC ISOPRENE RUBBERS, AND A HYDRAZIDE COMPOUND. BRIDGESTONE CORPORATION (JP) 2004-11-23 — — US disclosed
EP-1475408-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE MADE THEREFROM Bridgestone Corporation (JP) 2004-11-10 — — EP disclosed
US-6506849-B1 Natural or synthetic rubber; maleimide compound; and polyaniline, hydrazide and/or amine compound; workability, elasticity BRIDGESTONE CORPORATION (JP) 2003-01-14 — — US disclosed
US-20020049294-A1 Rubber composition and heavy duty pneumatic tire using the rubber composition BRIDGESTONE CORPORATION 2002-04-25 — — US disclosed
EP-1184412-A1 Rubber composition and heavy duty pneumetic tire using the rubber composition Bridgestone Corporation (JP) 2002-03-06 — — EP disclosed
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