Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 12/20 | 0.73 |
| ▸ | F13A1 | P00488 | 2/20 | 0.73 |
| ▸ | TGM1 | P22735 | 2/20 | 0.73 |
| ▸ | DPP4 | P27487 | 3/20 | 0.62 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.62 |
| ▸ | CCR1 | P32246 | 1/20 | 0.57 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.56 |
| ▸ | PRSS8 | Q16651 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.50 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.50 |
| ▸ | TGM6 | O95932 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15920180 | 0.85 | DPP4 (0.56) | TGM2F13A1TGM1DPP4DPP8 | |
| SCHEMBL15622903 | 0.85 | TGM2 (0.79) | TGM2F13A1TGM1TGM6 | |
| SCHEMBL17007561 | 0.85 | TGM2 (1.00) | TGM2F13A1TGM1TGM6 | |
| SCHEMBL7294359 | 0.84 | DPP4 (0.58) | TGM2F13A1TGM1DPP4DPP8 | |
| SCHEMBL28611635 | 0.84 | DPP4 (0.55) | TGM2F13A1TGM1DPP4DPP8 | |
| Hydrochloric Acid SCHEMBL6767096 | 0.83 | DPP4 (0.58) | TGM2F13A1TGM1DPP4DPP8 | |
| Hydrochloric Acid SCHEMBL28613884 | 0.83 | DPP4 (0.55) | TGM2F13A1TGM1DPP4DPP8 | |
| SCHEMBL15920174 | 0.82 | TGM2 (0.53) | TGM2F13A1TGM1DPP4DPP8 | |
| SCHEMBL2856646 | 0.81 | DPP4 (0.64) | TGM2F13A1TGM1DPP4DPP8 | |
| SCHEMBL2856638 | 0.81 | DPP4 (0.64) | TGM2F13A1TGM1DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014047288-A2 | TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | DOMINGUEZ CELIA (US) | 2014-03-27 | — | — | WO | disclosed |