Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.45 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.45 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL826512 | 1.00 | GSR (0.45) | GSRGRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL826933 | 0.88 | GSR (0.48) | GSRGRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL231631 | 0.88 | GSR (0.48) | GSRGRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL5668298 | 0.88 | GSR (0.48) | GSRGRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL10238195 | 0.86 | GSR (0.52) | GSRGRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL21083190 | 0.85 | GSR (0.50) | GSRGRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL826645 | 0.85 | GSR (0.50) | GSRGRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL11940102 | 0.82 | SLC7A5 (0.30) | SLC7A5 | |
| SCHEMBL19417862 | 0.81 | GSR (0.46) | GSRGRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL10418773 | 0.80 | ENPEP (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170022254-A1 | Novel Aldehyde Acetal Based Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates | NOVARTIS AG (CH) | 2017-01-26 | — | — | US | disclosed |
| WO-2015155676-A1 | NOVEL ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES | NOVARTIS AG (CH) | 2015-10-15 | — | — | WO | disclosed |
| EP-2906586-A2 | ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES | Novartis AG (CH) | 2015-08-19 | — | — | EP | disclosed |
| US-20150141615-A1 | ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES | NOVARTIS AG (CH) | 2015-05-21 | — | — | US | disclosed |
| US-20150141615-A1 | ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES | NOVARTIS AG (CH) | 2015-05-21 | — | — | US | disclosed |
| US-20150141615-A1 | ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES | NOVARTIS AG (CH) | 2015-05-21 | — | — | US | disclosed |
| US-8987413-B2 | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates | NOVARTIS AG (CH) | 2015-03-24 | — | — | US | disclosed |
| US-8987413-B2 | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates | NOVARTIS AG (CH) | 2015-03-24 | — | — | US | disclosed |
| US-8987413-B2 | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates | NOVARTIS AG (CH) | 2015-03-24 | — | — | US | disclosed |
| WO-2014057419-A2 | ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES | NOVARTIS AG (CH) | 2014-04-17 | — | — | WO | disclosed |
| WO-2014057419-A2 | ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES | NOVARTIS AG (CH) | 2014-04-17 | — | — | WO | disclosed |
| US-20140100353-A1 | ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES | NOVARTIS AG (CH) | 2014-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022254-A1 | Novel Aldehyde Acetal Based Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates | DNPEP, VIP, ALDH16A1 | GSR 3829/4885GRM8 4541/4885GRM6 4317/4885 |
| US-20140100353-A1 | ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES | DNPEP, VIP, ALDH16A1 | GSR 4172/4885GRM8 4406/4885GRM6 4161/4885 |
| US-20150141615-A1 | ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES | DNPEP, VIP, ALDH16A1 | GSR 4172/4885GRM8 4406/4885GRM6 4161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.