Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23901082 | 0.76 | MAP2K4 (0.47) | KDM4ESTAT3HIF1AALDH1A1LMNA | |
| SCHEMBL27992673 | 0.74 | GABRA1 (0.56) | KDM4ESTAT3HIF1AALDH1A1LMNA | |
| SCHEMBL1964170 | 0.74 | PDPK1 (0.50) | KDM4ESTAT3HIF1AALDH1A1LMNA | |
| SCHEMBL16277904 | 0.73 | CA12 (0.42) | STAT3ALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL1963000 | 0.72 | KDM4E (0.43) | KDM4ESTAT3HIF1AALDH1A1LMNA | |
| SCHEMBL8533 | 0.72 | ADORA2A (0.33) | — | |
| SCHEMBL5435670 | 0.71 | KDM4E (0.69) | KDM4ESTAT3HIF1AALDH1A1LMNA | |
| SCHEMBL1571777 | 0.71 | ALDH1A1 (0.34) | ALDH1A1LMNA | |
| SCHEMBL2191461 | 0.71 | GAA (0.35) | KDM4EALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL27694399 | 0.70 | DYRK1A (0.49) | KDM4ESTAT3HIF1AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-A1 | GDF-8 INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014055955-A1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2014-04-10 | — | — | WO | disclosed |