Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 5/20 | 0.46 |
| ▸ | BRAF | P15056 | 5/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.41 |
| ▸ | TUBB | P07437 | 4/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28582102 | 0.75 | LMNA (0.56) | LMNACYP1A2ALDH1A1HIF1AKDR | |
| Mebendazole SCHEMBL29409261 | 0.74 | ABL1 (0.82) | LMNACYP1A2ALDH1A1HIF1AKDR | |
| Mebendazole SCHEMBL3429179 | 0.74 | ABL1 (0.82) | LMNACYP1A2ALDH1A1HIF1AKDR | |
| Mebendazole SCHEMBL15860 | 0.74 | ABL1 (0.82) | LMNACYP1A2ALDH1A1HIF1AKDR | |
| Mebendazole SCHEMBL17262440 | 0.73 | ABL1 (0.80) | LMNACYP1A2ALDH1A1HIF1AKDR | |
| Mebendazole SCHEMBL21051203 | 0.73 | ABL1 (0.80) | LMNACYP1A2ALDH1A1HIF1AKDR | |
| Mebendazole SCHEMBL27690766 | 0.73 | ABL1 (0.80) | LMNACYP1A2ALDH1A1HIF1AKDR | |
| Mebendazole SCHEMBL21051200 | 0.73 | ABL1 (0.80) | LMNACYP1A2ALDH1A1HIF1AKDR | |
| Mebendazole SCHEMBL28186589 | 0.73 | ABL1 (0.80) | LMNACYP1A2ALDH1A1HIF1AKDR | |
| Mebendazole SCHEMBL28588780 | 0.72 | ABL1 (0.78) | LMNACYP1A2ALDH1A1HIF1AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |
| US-8697737-B2 | Raf modulators and methods of use | EXELIXIS, INC. (US) | 2014-04-15 | — | — | US | claimed |