Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14806639 | 1.00 | HSD11B1 (0.37) | HSD11B1HSD11B2VNN1CHRNB2CHRNB4 | |
| SCHEMBL616990 | 1.00 | HSD11B1 (0.37) | HSD11B1HSD11B2VNN1CHRNB2CHRNB4 | |
| SCHEMBL4322135 | 1.00 | HSD11B1 (0.37) | HSD11B1HSD11B2VNN1CHRNB2CHRNB4 | |
| SCHEMBL21460094 | 0.88 | VNN1 (0.39) | HSD11B1HSD11B2VNN1 | |
| SCHEMBL6127513 | 0.85 | HSD11B1 (0.42) | HSD11B1HSD11B2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6127508 | 0.85 | HSD11B1 (0.42) | HSD11B1HSD11B2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL27170220 | 0.81 | HSD11B1 (0.32) | HSD11B1HSD11B2 | |
| SCHEMBL30832718 | 0.79 | HSD11B1 (0.44) | HSD11B1HSD11B2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL22615698 | 0.78 | HSD11B1 (0.35) | HSD11B1HSD11B2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL22581181 | 0.78 | HSD11B1 (0.36) | HSD11B1HSD11B2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3773552-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019191229-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. (US) | 2019-10-03 | — | — | WO | disclosed |
| EP-2430006-B1 | CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-11-26 | — | — | EP | disclosed |
| US-8697883-B2 | Cyclopenta[C]pyrrole-2-carboxylate derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2014-04-15 | — | — | US | disclosed |