Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 3/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15652015 | 0.79 | HRH2 (0.59) | PSMB1PSMB5PSMB2LTA4HPTGS1 | |
| SCHEMBL188931 | 0.78 | MAPT (0.54) | KDM4EMEN1KMT2ADRD2ALDH1A1 | |
| SCHEMBL76551 | 0.76 | LTA4H (0.69) | PSMB1PSMB5PSMB2LTA4HPTGS1 | |
| SCHEMBL15542624 | 0.75 | LTA4H (0.67) | LTA4HPTGS1PTGS2KDM4EDRD3 | |
| SCHEMBL14204014 | 0.75 | LTA4H (0.67) | PSMB1PSMB5PSMB2LTA4HPTGS1 | |
| SCHEMBL15651282 | 0.75 | LTA4H (0.67) | PSMB1PSMB5PSMB2LTA4HPTGS1 | |
| SCHEMBL14453658 | 0.75 | DRD3 (0.54) | LTA4HPTGS1PTGS2DRD3KCNA5 | |
| SCHEMBL15651574 | 0.73 | LTA4H (0.60) | PSMB1PSMB5PSMB2LTA4HPTGS1 | |
| SCHEMBL56495 | 0.73 | LTA4H (0.90) | PSMB1PSMB5PSMB2LTA4HPTGS1 | |
| SCHEMBL15651047 | 0.72 | LTA4H (0.55) | PSMB1PSMB5PSMB2LTA4HPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014060112-A1 | PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2014-04-24 | — | — | WO | disclosed |