Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.54 |
| ▸ | GAA | P10253 | 7/20 | 0.54 |
| ▸ | GFER | P55789 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | RAD52 | P43351 | 2/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1815259 | 0.83 | MAPT (0.62) | MAPTGAAGFERKDM4ESMN1; SMN2 | |
| SCHEMBL943610 | 0.80 | MAPT (0.66) | MAPTGAAGFERKDM4ESMN1; SMN2 | |
| SCHEMBL15652016 | 0.78 | PSMB1 (0.53) | KDM4EALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL1018073 | 0.73 | MAPT (0.61) | MAPTGAAGFERKDM4ESMN1; SMN2 | |
| SCHEMBL5725588 | 0.73 | MAPT (0.61) | MAPTGAAGFERKDM4ESMN1; SMN2 | |
| SCHEMBL8236174 | 0.72 | MAPT (0.55) | MAPTGAAGFERKDM4ESMN1; SMN2 | |
| SCHEMBL24990305 | 0.72 | AR (0.66) | — | |
| SCHEMBL27805942 | 0.71 | MAPT (0.67) | MAPTGAAGFERKDM4ESMN1; SMN2 | |
| SCHEMBL158007 | 0.71 | MAPT (1.00) | MAPTGAAGFERKDM4ESMN1; SMN2 | |
| SCHEMBL6152136 | 0.71 | MAPT (1.00) | MAPTGAAGFERKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401281-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | MSD K.K. (JP) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010098367-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-02 | — | — | WO | disclosed |