Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 12/20 | 0.66 |
| ▸ | JAK2 | O60674 | 15/20 | 0.58 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15654412 | 0.87 | JAK1 (0.68) | JAK1JAK2JAK3TYK2 | |
| Cyclopropane SCHEMBL15653621 | 0.80 | JAK1 (0.78) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL15655082 | 0.80 | JAK2 (0.71) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2237694 | 0.79 | JAK1 (1.00) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL21797154 | 0.79 | JAK2 (0.63) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL15654821 | 0.78 | JAK1 (0.72) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL15655224 | 0.74 | JAK1 (0.69) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2730240 | 0.74 | NUDT1 (0.62) | JAK1JAK2 | |
| SCHEMBL15655295 | 0.73 | JAK1 (0.72) | JAK1JAK2JAK3TYK2 | |
| Cyclopropane SCHEMBL15653878 | 0.73 | JAK2 (0.81) | JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2361251-B1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2014-04-30 | — | — | EP | claimed |