Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.62 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29079138 | 0.87 | NUDT1 (0.61) | NUDT1JAK1JAK2EGLN2KDM4E | |
| SCHEMBL18154780 | 0.83 | JAK1 (0.44) | NUDT1JAK1JAK2EGLN2 | |
| SCHEMBL19659253 | 0.80 | EGLN2 (0.50) | NUDT1JAK1JAK2EGLN2PARP1 | |
| SCHEMBL19658699 | 0.79 | GRM2 (0.44) | NUDT1JAK1PIM1FYN | |
| SCHEMBL19658700 | 0.79 | NUDT1 (0.38) | NUDT1JAK1JAK2EGLN2PIM1 | |
| SCHEMBL28485655 | 0.78 | AHR (0.47) | NUDT1KDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL22439076 | 0.78 | KDM4E (0.43) | NUDT1KDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL19658973 | 0.77 | L3MBTL1 (0.36) | NUDT1JAK2KDM4EALDH1A1MAPK1 | |
| SCHEMBL2144054 | 0.77 | NUDT1 (1.00) | NUDT1JAK1JAK2EGLN2KDM4E | |
| SCHEMBL21797154 | 0.76 | JAK2 (0.63) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119462650-A | Non-goetide method for synthesizing nylon | 沈阳药科大学 | 2025-02-18 | — | — | CN | disclosed |
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |
| EP-3178819-A1 | 5-PHENYL-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-2-YL CARBOXAMIDES AS JAK INHIBITORS | Galapagos NV (BE) | 2017-06-14 | — | — | EP | disclosed |
| EP-2445911-B1 | 5-PHENYL-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-2-YL CARBOXAMIDES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2017-03-01 | — | — | EP | disclosed |
| CN-102482273-B | 5-phenyl- [1,2,4] triazolo [1,5-a ] pyridine-2-carboxamides as JAK inhibitors | GALAPAGOS NV | 2014-09-17 | — | — | CN | disclosed |
| CN-102482273-A | 5-phenyl- [1,2,4] triazolo [1,5-a ] pyridine-2-carboxamides as JAK inhibitors | GALAPAGOS NV | 2012-05-30 | — | — | CN | disclosed |
| EP-2445911-A1 | 5-PHENYL-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-2-YL CARBOXAMIDES AS JAK INHIBITORS | Galapagos N.V. (BE) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010149769-A1 | 5-PHENYL-[1,2,4 ]TRIAZOLO[1,5-A]PYRIDIN-2-YL CARBOXAMIDES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-12-29 | — | — | WO | disclosed |