Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PRNP | P04156 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2209836 | 0.91 | MAPT (0.58) | KDRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2204168 | 0.89 | MAPT (0.53) | KDRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2974053 | 0.88 | MAPT (0.52) | KDRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2209628 | 0.88 | MAPT (0.52) | KDRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2210397 | 0.88 | MAPT (0.52) | KDRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL15663446 | 0.86 | ENPP3 (0.56) | KDRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2208507 | 0.86 | MAPT (0.50) | KDRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL15663317 | 0.86 | ALDH1A1 (0.51) | KDRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL15663366 | 0.86 | MAPT (0.50) | KDRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL15663604 | 0.86 | MAPT (0.50) | KDRMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-05-07 | — | — | EP | disclosed |