Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15663871 | 0.90 | PDE10A (0.36) | PDE10AMAPTMAPK1LMNATSHR | |
| SCHEMBL15663669 | 0.87 | GRM5 (0.44) | NPC1RAB9ASMN1; SMN2MAPTGAA | |
| SCHEMBL15663562 | 0.82 | GRM5 (0.43) | PDE10ANPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL15664037 | 0.81 | PDE10A (0.45) | PDE10ANPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL15664201 | 0.81 | GRM5 (0.41) | PDE10ANPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL15663450 | 0.81 | GRM5 (0.41) | NPC1RAB9ASMN1; SMN2MAPTGAA | |
| SCHEMBL15663528 | 0.79 | GRM5 (0.48) | NPC1RAB9ASMN1; SMN2MAPTGAA | |
| SCHEMBL15664015 | 0.78 | PDE10A (0.41) | PDE10AGRM5 | |
| SCHEMBL15664024 | 0.78 | SMN1; SMN2 (0.41) | PDE10ANPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL15663949 | 0.77 | RAB9A (0.41) | NPC1RAB9ASMN1; SMN2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858854-B1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2014-05-07 | — | — | EP | claimed |