Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.45 |
| ▸ | TUBB | P07437 | 5/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.45 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.45 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23405224 | 0.91 | TUBB4A (0.55) | HDAC1HDAC6TUBB1TUBB4ATUBB | |
| SCHEMBL15665587 | 0.90 | HDAC1 (0.48) | HDAC1HDAC6TUBB1TUBB4ATUBB | |
| SCHEMBL15664653 | 0.90 | HDAC1 (0.50) | HDAC1HDAC6TUBB1TUBB4ATUBB | |
| SCHEMBL15664738 | 0.88 | DPP4 (0.46) | HDAC1HDAC6TUBB1TUBB4ATUBB | |
| SCHEMBL15664452 | 0.87 | HDAC1 (0.45) | HDAC1HDAC6TUBB1TUBB4ATUBB | |
| SCHEMBL15665220 | 0.87 | GSK3B (0.48) | HDAC1HDAC6TUBB1TUBB4ATUBB | |
| SCHEMBL15665015 | 0.84 | HDAC1 (0.44) | HDAC1HDAC6TUBB1TUBB4ATUBB | |
| Phosphoric Acid SCHEMBL15665039 | 0.83 | DPP4 (0.45) | HDAC1HDAC6TUBB1TUBB4ATUBB | |
| Phosphoric Acid SCHEMBL15664718 | 0.80 | DPP4 (0.43) | HDAC1HDAC6TUBB1TUBB4ATUBB | |
| SCHEMBL28807093 | 0.78 | HDAC1 (0.48) | HDAC1HDAC6TUBB1TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103889964-A | Tumor targeting drug Combretastatin A4 derivative | NANJING SANHOME PHARMACEUTICAL CO LTD | 2014-06-25 | — | — | CN | claimed |
| US-20140128384-A1 | TUMOR TARGETED DRUG COMBRETASTATIN A4 DERIVATIVE | NANJING SANHOME PHARMACEUTICAL CO., LTD. (CN) | 2014-05-08 | — | — | US | claimed |
| CN-105753787-B | Tumor-targeting drug Combretastatin A4 derivatives | 南京圣和药业股份有限公司 | 2018-05-15 | — | — | CN | disclosed |
| EP-2730565-B1 | TUMOR TARGETED DRUG COMBRETASTATIN A4 DERIVATIVE | NANJING SANHOME PHARMACEUTICAL CO LTD (CN) | 2017-04-26 | — | — | EP | disclosed |
| US-9139574-B2 | Tumor targeted drug combretastatin A4 derivative | NANJING SANHOME PHARMACEUTICAL CO., LTD. (CN) | 2015-09-22 | — | — | US | disclosed |
| EP-2730565-A1 | TUMOR TARGETED DRUG COMBRETASTATIN A4 DERIVATIVE | Nanjing Sanhome Pharmaceutical Co., Ltd. (CN) | 2014-05-14 | — | — | EP | disclosed |
| US-20140128384-A1 | TUMOR TARGETED DRUG COMBRETASTATIN A4 DERIVATIVE | NANJING SANHOME PHARMACEUTICAL CO., LTD. (CN) | 2014-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128384-A1 | TUMOR TARGETED DRUG COMBRETASTATIN A4 DERIVATIVE | TUBA4A, TUBGCP4, TUBB4A | HDAC1 171/4885HDAC6 13/4885TUBB1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.