Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 4/20 | 0.40 |
| ▸ | CTSK | P43235 | 4/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30697603 | 0.88 | TRPA1 (0.38) | CTSSCTSKTRPA1AAK1KLK5 | |
| SCHEMBL2891444 | 0.88 | TRPA1 (0.38) | CTSSCTSKTRPA1AAK1KLK5 | |
| SCHEMBL2898663 | 0.88 | TRPA1 (0.38) | CTSSCTSKTRPA1AAK1KLK5 | |
| SCHEMBL3822263 | 0.88 | CTSS (0.43) | KDM4DCTSSCTSKTRPA1AAK1 | |
| SCHEMBL29571131 | 0.88 | CTSS (0.43) | KDM4DCTSSCTSKTRPA1AAK1 | |
| SCHEMBL27189474 | 0.87 | TRPA1 (0.38) | CTSSCTSKTRPA1AAK1KLK5 | |
| SCHEMBL29483428 | 0.87 | KDM4D (0.41) | KDM4DCTSSCTSKTRPA1AAK1 | |
| SCHEMBL1115364 | 0.87 | KDM4D (0.41) | KDM4DCTSSCTSKTRPA1AAK1 | |
| SCHEMBL23969949 | 0.85 | AAK1 (0.40) | KDM4DCTSSCTSKTRPA1AAK1 | |
| SCHEMBL15670451 | 0.84 | CTSS (0.45) | CTSSCTSKKLK5S1PR3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200171028-A1 | METALLOENZYME INHIBITOR COMPOUNDS | VIAMET PHARMACEUTICALS HOLDINGS, LLC | 2020-06-04 | — | — | US | disclosed |
| EP-2912034-B1 | 3,4-DISUBSTITUTED OXAZOLIDINONE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE CALCIUM ACTIVATED POTASSIUM CHANNEL | HOFFMANN LA ROCHE (CH) | 2017-05-31 | — | — | EP | disclosed |
| US-9611232-B2 | Oxazolidinone and imidazolidinone compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-20150246894-A1 | NOVEL OXAZOLIDINONE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-09-03 | — | — | US | disclosed |
| EP-2912034-A1 | 3,4-DISUBSTITUTED OXAZOLIDINONE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE CALCIUM ACTIVATED POTASSIUM CHANNEL | F. Hoffmann-La Roche AG (CH) | 2015-09-02 | — | — | EP | disclosed |
| WO-2014067861-A1 | 3,4-DISUBSTITUTED OXAZOLIDINONE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE CALCIUM ACTIVATED POTASSIUM CHANNEL | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246894-A1 | NOVEL OXAZOLIDINONE COMPOUNDS | OXA1L, CDK11B, CDK11A | KDM4D 2606/4885CTSS 4536/4885CTSK 3065/4885 |
| US-20200171028-A1 | METALLOENZYME INHIBITOR COMPOUNDS | HDAC6, HDAC1, HDAC2 | KDM4D 3433/4885CTSS 431/4885CTSK 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.