Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | KDM1A | O60341 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4531997 | 0.93 | POLB (0.86) | POLBKMT2AKDM1AMAOAMAOB | |
| SCHEMBL16464079 | 0.84 | POLB (0.76) | POLBKMT2AKDM1AMAOAMAOB | |
| SCHEMBL3087992 | 0.84 | POLB (0.76) | POLBKMT2AKDM1AMAOAMAOB | |
| SCHEMBL4523282 | 0.79 | POLB (0.64) | POLBKMT2AKDM1AMAOAMAOB | |
| Hydrochloric Acid SCHEMBL6465958 | 0.79 | POLB (0.51) | POLBKMT2AKDM1AMAOAMAOB | |
| SCHEMBL5403403 | 0.79 | ACHE (0.78) | POLBKMT2ABCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL6465949 | 0.79 | POLB (0.51) | POLBKMT2AKDM1AMAOAMAOB | |
| SCHEMBL15670820 | 0.77 | POLB (0.61) | POLBKMT2AKDM1AMAOAMAOB | |
| SCHEMBL16665158 | 0.76 | TACR1 (0.48) | POLBKMT2AMAOAMAOBALDH1A1 | |
| SCHEMBL18047320 | 0.76 | TACR1 (0.48) | POLBKMT2AMAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2914590-B1 | NOVEL ROCK INHIBITORS | PH PHARMA CO LTD (KR) | 2016-11-30 | — | — | EP | disclosed |
| US-9394286-B2 | Rock inhibitors | AMAKEM NV (BE) | 2016-07-19 | — | — | US | disclosed |
| US-20150299173-A1 | NOVEL ROCK INHIBTORS | AMAKEM NV (BE) | 2015-10-22 | — | — | US | disclosed |
| EP-2914590-A1 | NOVEL ROCK INHIBITORS | Amakem NV (BE) | 2015-09-09 | — | — | EP | disclosed |
| WO-2014068035-A1 | NOVEL ROCK INHIBITORS | AMAKEM NV (BE) | 2014-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299173-A1 | NOVEL ROCK INHIBTORS | ROCK1, ROCK2, CIT | POLB 3481/4885KMT2A 3390/4885KDM1A 1582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.