Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.45 |
| ▸ | SI | P14410 | 1/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18551876 | 0.91 | KMT2A (0.57) | L3MBTL1NPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL12971324 | 0.88 | NPC1 (0.52) | L3MBTL1NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL657566 | 0.86 | ALDH1A1 (0.46) | L3MBTL1NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL18551753 | 0.86 | ALDH1A1 (0.41) | L3MBTL1NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL18551794 | 0.83 | ALDH1A1 (0.45) | L3MBTL1NPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9872402 | 0.81 | GAA (0.49) | NPC1ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL18551820 | 0.81 | KMT2A (0.43) | L3MBTL1NPC1ALDH1A1LMNAKMT2A | |
| SCHEMBL16669979 | 0.79 | ALDH1A1 (0.46) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL10253421 | 0.79 | NPC1 (0.41) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7404983 | 0.79 | ALOX15 (0.43) | L3MBTL1ALDH1A1MAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483242-B1 | New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers | IKERCHEM S L (ES) | 2013-12-11 | — | — | EP | disclosed |
| EP-2483242-A1 | NEW HISTONE DEACETYLASE INHIBITORS BASED SIMULTANEOUSLY ON TRISUBSTITUTED 1H-PYRROLES AND AROMATIC AND HETEROAROMATIC SPACERS | Ikerchem, S.L. (ES) | 2012-08-08 | — | — | EP | disclosed |
| US-20120196885-A1 | NEW HISTONE DEACETYLASE INHIBITORS BASED SIMULTANEOUSLY ON TRISUBSTITUTED 1H-PYRROLES AND AROMATIC AND HETEROAROMATIC SPACERS | IKERCHEM, S.L. (ES) | 2012-08-02 | — | — | US | disclosed |
| WO-2011039353-A1 | NEW HISTONE DEACETYLASE INHIBITORS BASED SIMULTANEOUSLY ON TRISUBSTITUTED 1H-PYRROLES AND AROMATIC AND HETEROAROMATIC SPACERS | IKERCHEM, S.L. (ES) | 2011-04-07 | — | — | WO | disclosed |
| EP-2305643-A1 | New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers | Ikerchem, S.L. (ES) | 2011-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196885-A1 | NEW HISTONE DEACETYLASE INHIBITORS BASED SIMULTANEOUSLY ON TRISUBSTITUTED 1H-PYRROLES AND AROMATIC AND HETEROAROMATIC SPACERS | HDAC1, HDAC3, HDAC11 | L3MBTL1 1302/4885NPC1 4362/4885ALDH1A1 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.