Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.67 |
| ▸ | FES | P07332 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 1/20 | 0.65 |
| ▸ | MARK3 | P27448 | 1/20 | 0.65 |
| ▸ | TYK2 | P29597 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 1/20 | 0.65 |
| ▸ | SYK | P43405 | 1/20 | 0.65 |
| ▸ | CLK2 | P49760 | 1/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29684017 | 0.89 | NAMPT (0.76) | NAMPTFESRETMARK3TYK2 | |
| SCHEMBL20236126 | 0.88 | CYP1A2 (0.66) | NAMPTRECQLUSP2POLBGAA | |
| SCHEMBL29460250 | 0.87 | FES (0.81) | NAMPTFESRETMARK3TYK2 | |
| SCHEMBL9130703 | 0.87 | FES (0.81) | NAMPTFESRETMARK3TYK2 | |
| SCHEMBL1567228 | 0.84 | SMN1; SMN2 (0.68) | NAMPTKMT2ASMN1; SMN2L3MBTL1POLB | |
| SCHEMBL1566393 | 0.83 | CYP3A4 (0.73) | KMT2ASMN1; SMN2GAACYP1A2CYP3A4 | |
| SCHEMBL2434821 | 0.82 | HDAC1 (0.78) | NAMPTCYP3A4 | |
| SCHEMBL2410964 | 0.82 | HDAC1 (0.70) | NAMPTSMN1; SMN2CYP3A4HTT | |
| SCHEMBL2636669 | 0.81 | LTA4H (0.69) | NAMPTKMT2ARECQLUSP2CYP1A2 | |
| SCHEMBL14323610 | 0.80 | FLT4 (0.97) | NAMPTFESRETMARK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106986856-A | It is used as 4 { [(ylmethyl of pyridine 3) amino carbonyl] amino } Benzosulfone derivatives of the NAMPT inhibitor for treating diseases such as cancer | 福马TM有限责任公司 | 2017-07-28 | — | — | CN | disclosed |
| US-8889876-B2 | Histone deacetylase inhibitors and uses thereof | JIANGSU HENGYI PHARMACEUTICAL CO., LTD. (CN) | 2014-11-18 | — | — | US | disclosed |
| US-20110152323-A1 | Histone deacetylase inhibitors and uses thereof | JIANGSU GOWORTH INVESTMENT CO. LTD (CN) | 2011-06-23 | — | — | US | disclosed |
| EP-2308868-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | Jiangsu Goworth Investment Co. Ltd (CN) | 2011-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152323-A1 | Histone deacetylase inhibitors and uses thereof | HDAC1, HDAC11, HDAC5 | NAMPT 218/4885FES 4300/4885RET 2199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.