Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | CALCRL | Q16602 | 7/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL830235 | 1.00 | HTR1A (0.35) | HTR1ASLC6A2SLC6A4CALCRLADRB2 | |
| SCHEMBL31463313 | 1.00 | HTR1A (0.35) | HTR1ASLC6A2SLC6A4CALCRLADRB2 | |
| SCHEMBL15674592 | 1.00 | HTR1A (0.35) | HTR1ASLC6A2SLC6A4CALCRLADRB2 | |
| SCHEMBL829272 | 1.00 | HTR1A (0.35) | HTR1ASLC6A2SLC6A4CALCRLADRB2 | |
| SCHEMBL1670251 | 0.81 | CYP19A1 (0.40) | CYP19A1 | |
| SCHEMBL828687 | 0.80 | CYP19A1 (0.38) | HTR1ASLC6A2SLC6A4CALCRLCYP19A1 | |
| SCHEMBL30828014 | 0.78 | P2RX7 (0.45) | CYP19A1P2RX7 | |
| SCHEMBL1670637 | 0.78 | P2RX7 (0.45) | CYP19A1P2RX7 | |
| SCHEMBL12801798 | 0.78 | P2RX7 (0.45) | CYP19A1P2RX7 | |
| SCHEMBL16615999 | 0.78 | CALCRL (0.38) | HTR1ASLC6A2SLC6A4CALCRLADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150361047-A1 | Process for the Preparation of Cycloheptapyridine CGRP Receptor Antagonists | BRISTOL MYERS SQUIBB CO (US) | 2015-12-17 | — | — | US | disclosed |
| US-20150099887-A1 | PROCESS FOR THE PREPARATION OF CYCLOHEPTAPYRIDINE CGRP RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2015-04-09 | — | — | US | disclosed |
| US-20140135500-A1 | Process for the Preparation of Cycloheptapyridine CGRP Receptor Antagonists | BRISTOL MYERS SQUIBB CO (US) | 2014-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150361047-A1 | Process for the Preparation of Cycloheptapyridine CGRP Receptor Antagonists | CALCRL, OPRL1, CALCR | HTR1A 59/4885SLC6A2 598/4885SLC6A4 398/4885 |
| US-20150099887-A1 | PROCESS FOR THE PREPARATION OF CYCLOHEPTAPYRIDINE CGRP RECEPTOR ANTAGONISTS | CALCRL, OPRL1, CALCR | HTR1A 59/4885SLC6A2 598/4885SLC6A4 398/4885 |
| US-20140135500-A1 | Process for the Preparation of Cycloheptapyridine CGRP Receptor Antagonists | CALCRL, OPRL1, CALCR | HTR1A 59/4885SLC6A2 598/4885SLC6A4 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.