Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4266089 | 0.86 | DHFR (0.41) | DHFRMEN1KMT2AHSP90AA1ADORA2A | |
| SCHEMBL1517137 | 0.74 | LCK (0.59) | DHFRMEN1KMT2AHSP90AA1ADORA2A | |
| SCHEMBL4264063 | 0.73 | DHFR (0.43) | DHFRMEN1KMT2AHSP90AA1ADORA2A | |
| SCHEMBL4266090 | 0.72 | MEN1 (0.40) | DHFRMEN1KMT2AHSP90AA1ADORA2A | |
| SCHEMBL29973127 | 0.72 | MEN1 (0.45) | MEN1KMT2AS1PR1ALDH1A1 | |
| SCHEMBL7799233 | 0.68 | ADORA2A (0.62) | DHFRMEN1KMT2AHSP90AA1ADORA2A | |
| SCHEMBL6679657 | 0.66 | DHFR (0.35) | DHFRNQO2PDPK1 | |
| SCHEMBL6679667 | 0.65 | NQO2 (0.36) | DHFRNQO2PDPK1 | |
| SCHEMBL10493961 | 0.65 | PLA2G7 (0.50) | MEN1KMT2AHSP90AA1ADORA2AS1PR1 | |
| SCHEMBL1517001 | 0.64 | MEN1 (0.41) | MEN1KMT2ALCKKDRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809614-B1 | BENZOTRIAZINE INHIBITORS OF KINASES | TARGEGEN INC (US) | 2014-05-07 | — | — | EP | disclosed |