Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.49 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26947058 | 0.82 | PTPN1 (0.46) | MAPTKMT2AMEN1GAAKDM4E | |
| SCHEMBL16666119 | 0.81 | PTPN1 (0.46) | MAPTKMT2AMEN1GAAKDM4E | |
| SCHEMBL30486708 | 0.81 | MAOB (0.44) | GAAL3MBTL1HTT | |
| SCHEMBL26947064 | 0.81 | MAOB (0.44) | GAAL3MBTL1HTT | |
| SCHEMBL17038133 | 0.80 | CYP1A2 (0.49) | MAPTKMT2AMEN1GAAKDM4E | |
| Fostedil SCHEMBL29387277 | 0.80 | KDM4E (0.53) | MAPTKMT2AMEN1GAAKDM4E | |
| Fostedil SCHEMBL612913 | 0.80 | KDM4E (0.53) | MAPTKMT2AMEN1GAAKDM4E | |
| SCHEMBL30132337 | 0.80 | CYP1A2 (0.49) | MAPTKMT2AMEN1GAAKDM4E | |
| SCHEMBL7407470 | 0.78 | F2RL3 (0.47) | MAPTKMT2AMEN1GAAKDM4E | |
| SCHEMBL4406283 | 0.76 | UBE2T (0.56) | MAPTKMT2AMEN1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238187-A1 | AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES | WILLIAM MARSH RICE UNIVERSITY (US) | 2021-08-05 | — | — | US | disclosed |
| US-10874646-B2 | Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof | WILLIAM MARSH RICE UNIVERSITY (US) | 2020-12-29 | — | — | US | disclosed |
| US-20190022069-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2019-01-24 | — | — | US | disclosed |
| WO-2017066606-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-04-20 | — | — | WO | disclosed |
| WO-2014072930-A2 | FUSED PYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874646-B2 | Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof | EPOR, CD47, DHPS | MAPT 3333/4885KMT2A 3574/4885MEN1 2203/4885 |
| US-20190022069-A1 | EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF | EPOR, CD47, DHPS | MAPT 3333/4885KMT2A 3574/4885MEN1 2203/4885 |
| US-20210238187-A1 | AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES | EPOR, EZR, CD47 | MAPT 4222/4885KMT2A 2781/4885MEN1 2437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.