Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CAD | P27708 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.32 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.32 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15710689 | 1.00 | ALOX15 (0.44) | ALOX15ALDH1A1LMNAHSD17B10CYP2D6 | |
| SCHEMBL15887768 | 0.75 | ALOX15 (0.44) | ALOX15ALDH1A1LMNAHSD17B10CYP2D6 | |
| SCHEMBL27656796 | 0.74 | ALOX15 (0.48) | ALOX15ALDH1A1LMNAHSD17B10CYP2D6 | |
| SCHEMBL28210437 | 0.74 | ALOX15 (0.48) | ALOX15ALDH1A1LMNAHSD17B10MGAM | |
| SCHEMBL1135174 | 0.74 | ALOX15 (0.48) | ALOX15ALDH1A1LMNAHSD17B10CYP2D6 | |
| SCHEMBL5073341 | 0.72 | ALOX15 (0.46) | ALOX15ALDH1A1LMNAHSD17B10MGAM | |
| SCHEMBL28111664 | 0.72 | ALOX15 (0.46) | ALOX15ALDH1A1LMNAHSD17B10MGAM | |
| SCHEMBL28210435 | 0.72 | ALOX15 (0.46) | ALOX15ALDH1A1LMNAHSD17B10CYP2D6 | |
| SCHEMBL15015528 | 0.71 | ALOX15 (0.44) | ALOX15ALDH1A1LMNAHSD17B10MGAM | |
| SCHEMBL11418961 | 0.71 | ALDH1A1 (0.41) | ALOX15ALDH1A1LMNAHSD17B10CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160257686-A1 | Purinone Derivatives as Tyrosine Kinase Inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20140142099-A1 | Purinone Derivatives as Tyrosine Kinase Inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142099-A1 | Purinone Derivatives as Tyrosine Kinase Inhibitors | BMX, BLK, ITK | ALOX15 1353/4885ALDH1A1 4110/4885LMNA 4213/4885 |
| US-20160257686-A1 | Purinone Derivatives as Tyrosine Kinase Inhibitors | BMX, BLK, ITK | ALOX15 1353/4885ALDH1A1 4110/4885LMNA 4213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.