Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14614677 | 0.78 | MKNK2 (0.43) | SCN9AKDRMEN1KMT2AMKNK1 | |
| SCHEMBL14614612 | 0.75 | MKNK2 (0.47) | SCN9AKDRMKNK1MKNK2CDK1 | |
| SCHEMBL13116795 | 0.73 | MAPK10 (0.53) | EGFRERBB3CDK2MAPK10GAA | |
| SCHEMBL1094303 | 0.72 | MEN1 (0.53) | EGFRERBB3SCN9AKDRMEN1 | |
| SCHEMBL28936119 | 0.72 | MKNK1 (0.66) | MKNK1 | |
| SCHEMBL30781995 | 0.70 | SCN9A (0.50) | EGFRERBB3SCN9AKDRMEN1 | |
| SCHEMBL15711333 | 0.69 | MAPK10 (0.62) | EGFRSCN9AKDRMEN1KMT2A | |
| SCHEMBL9396539 | 0.69 | KDM4E (0.47) | MEN1KMT2AGAAMAPTL3MBTL1 | |
| SCHEMBL10187337 | 0.69 | MEN1 (0.81) | EGFRERBB3SCN9AMEN1KMT2A | |
| SCHEMBL1095089 | 0.68 | MEN1 (0.52) | EGFRERBB3SCN9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336122-B1 | 1-PYRIMIDINYL- OR 1-PYRIDINYL-2-AMINO BENZIMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF PROTEIN KINASES FOR THE TREATMENT OF CANCER | VERTEX PHARMA (US) | 2014-05-14 | — | — | EP | disclosed |