Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | IDE | P14735 | 1/20 | 0.57 |
| ▸ | MPI | P34949 | 1/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.57 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.57 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.53 |
| ▸ | DDO | Q99489 | 1/20 | 0.53 |
| ▸ | CTSV | O60911 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15194482 | 0.88 | MAPT (0.77) | MAPK14MAPTKDM4EALDH1A1IDE | |
| SCHEMBL29709937 | 0.87 | MAPT (0.75) | MAPTKDM4EALDH1A1IDEMPI | |
| SCHEMBL5396117 | 0.87 | MAPT (0.75) | MAPTKDM4EALDH1A1IDEMPI | |
| SCHEMBL15690335 | 0.84 | FASN (0.49) | MAPK14MAPTKDM4ESERPINE1PADI4 | |
| SCHEMBL4897721 | 0.81 | MAPK14 (0.63) | MAPK14MAPTKDM4EALDH1A1SERPINE1 | |
| SCHEMBL17158382 | 0.78 | MAPK14 (0.59) | MAPK14MAPTKDM4EALDH1A1CTSV | |
| SCHEMBL4895208 | 0.76 | KDM4E (0.61) | MAPK14MAPTKDM4EALDH1A1CTSV | |
| SCHEMBL17942038 | 0.76 | KDM4E (0.69) | MAPTKDM4EALDH1A1IDEMPI | |
| SCHEMBL7042862 | 0.76 | MAPK14 (0.81) | MAPK14MAPTKDM4ECTSVCTSL | |
| SCHEMBL6257903 | 0.76 | PTGS2 (0.59) | MAPK14MAPTKDM4ESERPINE1CTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701638-B2 | Therapeutic hydroxyquinolones | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-07-11 | — | — | US | disclosed |
| US-9701638-B2 | Therapeutic hydroxyquinolones | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-07-11 | — | — | US | disclosed |
| US-20150291531-A1 | THERAPEUTIC HYDROXYQUINOLONES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2015-10-15 | — | — | US | disclosed |
| US-20150291531-A1 | THERAPEUTIC HYDROXYQUINOLONES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2015-10-15 | — | — | US | disclosed |
| WO-2014074926-A1 | THERAPEUTIC HYDROXYQUINOLONES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2014-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291531-A1 | THERAPEUTIC HYDROXYQUINOLONES | RECQL, DDX5, DHX35 | MAPK14 4338/4885MAPT 4639/4885KDM4E 1278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.