Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15532493 | 0.83 | KDM4E (0.55) | JMJD6NPC1RAB9AVNN1HTT | |
| SCHEMBL30153493 | 0.83 | KDM4E (0.55) | JMJD6NPC1RAB9AVNN1HTT | |
| SCHEMBL28544252 | 0.80 | DDR1 (0.42) | JMJD6CA12CA1CA2CA9 | |
| SCHEMBL3114077 | 0.80 | JMJD6 (0.56) | JMJD6CA12CA1CA2CA7 | |
| SCHEMBL16689607 | 0.80 | DDR1 (0.44) | MEN1KMT2AVNN1 | |
| SCHEMBL30252196 | 0.80 | VNN1 (0.43) | MEN1KMT2AVNN1 | |
| SCHEMBL10772838 | 0.79 | JMJD6 (0.76) | JMJD6CA12CA1CA2CA7 | |
| SCHEMBL15720401 | 0.79 | SYK (0.54) | JMJD6CA12CA1CA2CA7 | |
| SCHEMBL1974937 | 0.78 | JMJD6 (0.57) | JMJD6CA12CA1CA2CA7 | |
| SCHEMBL15253922 | 0.78 | JMJD6 (0.57) | JMJD6CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104781236-B | The method for preparing 2- trifluoromethyls isonicotinic acid and ester | 霍夫曼-拉罗奇有限公司 | 2018-04-24 | — | — | CN | disclosed |
| EP-2920150-B1 | PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS | HOFFMANN LA ROCHE (CH) | 2017-07-19 | — | — | EP | disclosed |
| US-9481650-B2 | Process for the preparation of 2-trifluoromethyl isonicotinic acid and esters | HOFFMANN LA ROCHE INC. (US) | 2016-11-01 | — | — | US | disclosed |
| US-20150291530-A1 | PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-15 | — | — | US | disclosed |
| EP-2920150-A1 | PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS | F. Hoffmann-La Roche AG (CH) | 2015-09-23 | — | — | EP | disclosed |
| CN-104781236-A | Process for the preparation of 2-trifluoromethyl isonicotinic acid and esters | HOFFMANN LA ROCHE | 2015-07-15 | — | — | CN | disclosed |
| WO-2014076127-A1 | PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291530-A1 | PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS | TAAR1, TAAR5, TSHR | JMJD6 1617/4885CA12 1133/4885CA1 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.