Lapachol

Lapachol

SCHEMBL157255

CC(C)=CCC1=C(O)C(=O)c2ccccc2C1=O

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 6/20 0.79
MAPT P10636 3/20 0.79
KDM4E B2RXH2 2/20 0.79
MEN1 O00255 2/20 0.79
KMT2A Q03164 2/20 0.79
ALDH1A1 P00352 2/20 0.79
SMN1; SMN2 Q16637 2/20 0.79
TP53 P04637 1/20 0.79
CYP3A4 P08684 1/20 0.79
PKM P14618 1/20 0.79
CDC25A P30304 1/20 0.79
CDC25B P30305 1/20 0.79
RPS6KA3 P51812 1/20 0.79
GLO1 Q04760 1/20 0.79
GPR35 Q9HC97 1/20 0.79
APAF1 O14727 2/20 0.58
TDP2 O95551 2/20 0.58
CYP1A2 P05177 2/20 0.58
CYP2C9 P11712 2/20 0.58
HIF1A Q16665 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lapachol SCHEMBL31492698 1.00 DHODH (0.79) DHODHMAPTKDM4EMEN1KMT2A
Lapachol SCHEMBL3274147 0.98 DHODH (0.77) DHODHMAPTKDM4EMEN1KMT2A
Lapachol SCHEMBL18769814 0.98 DHODH (0.77) DHODHMAPTKDM4EMEN1KMT2A
Lapachol SCHEMBL18037006 0.92 DHODH (0.68) DHODHMAPTKDM4EMEN1KMT2A
Lapachol SCHEMBL7362189 0.91 MAPT (0.67) DHODHMAPTKDM4EMEN1KMT2A
Lapachol SCHEMBL28491462 0.90 DHODH (0.65) DHODHMAPTKDM4EMEN1KMT2A
SCHEMBL157256 0.88 DHODH (1.00) DHODHMAPTKDM4EMEN1KMT2A
SCHEMBL14236459 0.87 DHODH (0.66) DHODHMAPTKDM4EMEN1KMT2A
SCHEMBL20811074 0.87 DHODH (0.70) DHODHMAPTKDM4EMEN1KMT2A
SCHEMBL974935 0.87 MAPT (0.74) DHODHMAPTKDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5674 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4714440-A2 A HEALING HERBAL-MINERAL COMPOSITION WITH ENHANCED EFFECTS Kurek, Janusz (PL) 2026-03-25 EP claimed
US-20260069517-A1 SKIN CARE PRODUCT WITH LAPACHOL SALZINGER STEVE (US) 2026-03-12 US claimed
EP-4674894-A2 COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES Hemoteq AG (DE) 2026-01-07 EP claimed
EP-4663688-A2 CROSSLINKERS Hemoteq AG (DE) 2025-12-17 EP claimed
US-20250319042-A1 SKIN CARE PRODUCT WITH LAPACHOL AND METHOD FOR USE THEREOF SALZINGER STEVE (US) 2025-10-16 US claimed
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
US-11896709-B2 Natural vegetable source based hair colour GODREJ CONSUMER PRODUCTS LTD. (IN) 2024-02-13 US claimed
US-20230270662-A1 NATURAL VEGETABLE SOURCE BASED HAIR COLOUR GODREJ CONSUMER PRODUCTS LTD. (IN) 2023-08-31 US claimed
CN-116616287-A Pesticide composition for preventing dwarf disease of rice 广西宸晗农业发展有限公司 2023-08-22 CN claimed
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2023-03-23 US claimed
US-6458974-B1 Synthesis of β-lapachone and its intermediates CYCLIS PHARMACEUTICALS, INC. 2002-10-01 US claimed
US-6458168-B1 Hair dyeing method using an aliphatic cationic amine and compound chosen from an aldehyde, a ketone, a quinone, a di-imino-isoindoline, and a 3-aminoisoindolone derivative L'OREAL S.A. (FR) 2002-10-01 US claimed
US-20020137952-A1 SYNTHESIS OF BETA-LAPACHONE AND ITS INTERMEDIATES ARQULE, INC. 2002-09-26 US claimed
US-6451067-B1 HAIR DYE MIXTURE L'OREAL S.A. (FR) 2002-09-17 US claimed
WO-2002059103-A1 SYNTHESIS OF BETA-LAPACHONE AND ITS INTERMEDIATES CYCLIS PHARMACEUTICALS, INC. (US) 2002-08-01 WO claimed
WO-1996033988-A1 NOVEL SYNTHESIS AND USE OF BETA-LAPACHONE ANALOGS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1996-10-31 WO claimed
WO-1993019143-A1 COLORANT-CONTAINING ELECTRORHEOLOGICAL MATERIALS LORD CORPORATION (US) 1993-09-30 WO claimed
US-5241022-A Polyvinyl alcohol with saponification of not less than seventy percent and quinone SHIN-ETSU CHEMICAL CO., LTD. (JP) 1993-08-31 US claimed
EP-0496349-A1 Coating solution for preventing adhesion of polymer scale and method for its use SHIN-ETSU CHEMICAL CO., LTD. (JP) 1992-07-29 EP claimed
EP-0124393-A1 Hair dyeing composition and process ALBAN MULLER INTERNATIONAL, S.A.R.L. (FR) 1984-11-07 EP claimed