Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | DHODH | Q02127 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | PKM | P14618 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CDC25A | P30304 | 1/20 | 0.67 |
| ▸ | CDC25B | P30305 | 1/20 | 0.67 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.67 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.67 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.67 |
| ▸ | APAF1 | O14727 | 2/20 | 0.54 |
| ▸ | TDP2 | O95551 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | NSD2 | O96028 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lapachol SCHEMBL157255 | 0.91 | DHODH (0.79) | MAPTDHODHALDH1A1MEN1KMT2A | |
| Lapachol SCHEMBL31492698 | 0.91 | DHODH (0.79) | MAPTDHODHALDH1A1MEN1KMT2A | |
| Lapachol SCHEMBL18769814 | 0.90 | DHODH (0.77) | MAPTDHODHALDH1A1MEN1KMT2A | |
| Lapachol SCHEMBL3274147 | 0.90 | DHODH (0.77) | MAPTDHODHALDH1A1MEN1KMT2A | |
| Lapachol SCHEMBL18037006 | 0.84 | DHODH (0.68) | MAPTDHODHALDH1A1MEN1KMT2A | |
| Lapachol SCHEMBL28491462 | 0.82 | DHODH (0.65) | MAPTDHODHALDH1A1MEN1KMT2A | |
| SCHEMBL157256 | 0.80 | DHODH (1.00) | MAPTDHODHALDH1A1MEN1KMT2A | |
| SCHEMBL20811074 | 0.79 | DHODH (0.70) | MAPTDHODHALDH1A1MEN1KMT2A | |
| SCHEMBL14236459 | 0.79 | DHODH (0.66) | MAPTDHODHALDH1A1MEN1KMT2A | |
| SCHEMBL974935 | 0.79 | MAPT (0.74) | MAPTDHODHALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996033988-A1 | NOVEL SYNTHESIS AND USE OF BETA-LAPACHONE ANALOGS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1996-10-31 | — | — | WO | claimed |