Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dodecanoate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.54 |
| ▸ | CES1 | P23141 | 2/20 | 0.54 |
| ▸ | FABP3 | P05413 | 7/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Decanoic Acid SCHEMBL10862164 | 0.97 | CES2 (0.57) | CES2CES1FABP3PPARGCA1 | |
| Octanoic Acid SCHEMBL2807929 | 0.97 | CES2 (0.57) | CES2CES1FABP3PPARGCA1 | |
| Dodecanoate SCHEMBL10935524 | 0.97 | CES2 (0.57) | CES2CES1FABP3PPARGCA1 | |
| Oleic Acid SCHEMBL8922825 | 0.88 | FABP3 (0.71) | FABP3PPARGEPHX2 | |
| Oleic Acid SCHEMBL2808350 | 0.88 | FABP3 (0.71) | FABP3PPARGEPHX2 | |
| Octanoic Acid SCHEMBL106093 | 0.83 | CES2 (0.54) | CES2CES1FABP3PPARGCA1 | |
| Stearic Acid SCHEMBL109141 | 0.83 | CES2 (0.54) | CES2CES1FABP3PPARGCA1 | |
| Decanoic Acid SCHEMBL109283 | 0.83 | CES2 (0.54) | CES2CES1FABP3PPARGCA1 | |
| Dodecanoate SCHEMBL4587316 | 0.83 | CES2 (0.54) | CES2CES1FABP3PPARGCA1 | |
| Heptanoate SCHEMBL107320 | 0.83 | CES2 (0.54) | CES2CES1FABP3PPARGCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611868-B1 | BIODEGRADABLE TERPOLYMERS AND TERPOLYMER BLENDS AS PRESSURE-SENSITIVE ADHESIVES | SURMODICS PHARMACEUTICALS INC (US) | 2020-01-08 | — | — | EP | disclosed |
| US-9416221-B2 | Biodegradable terpolymers and terpolymer blends as pressure-sensitive adhesives | SURMODICS, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| EP-2611868-A1 | BIODEGRADABLE TERPOLYMERS AND TERPOLYMER BLENDS AS PRESSURE-SENSITIVE ADHESIVES | Surmodics Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| US-20120078155-A1 | BIODEGRADABLE TERPOLYMERS AND TERPOLYMER BLENDS AS PRESSURE-SENSITIVE ADHESIVES | BANK OF MONTREAL, AS COLLATERAL AGENT | 2012-03-29 | — | — | US | disclosed |
| WO-2012030823-A1 | BIODEGRADABLE TERPOLYMERS AND TERPOLYMER BLENDS AS PRESSURE-SENSITIVE ADHESIVES | SURMODICS PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |