Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15726611 | 1.00 | KDM4E (0.37) | KDM4ETDP1ALDH1A1GAAPOLB | |
| SCHEMBL15709262 | 1.00 | KDM4E (0.37) | KDM4ETDP1ALDH1A1GAAPOLB | |
| SCHEMBL15726589 | 0.81 | KDM4E (0.35) | KDM4ETDP1ALDH1A1GAAPOLB | |
| SCHEMBL31490487 | 0.68 | KDM4E (0.43) | KDM4ETDP1ALDH1A1GAAPOLB | |
| SCHEMBL195658 | 0.68 | KDM4E (0.43) | KDM4ETDP1ALDH1A1GAAPOLB | |
| SCHEMBL3112271 | 0.68 | KDM4E (0.43) | KDM4ETDP1ALDH1A1GAAPOLB | |
| SCHEMBL10338131 | 0.68 | KDM4E (0.43) | KDM4ETDP1ALDH1A1GAAPOLB | |
| SCHEMBL15726659 | 0.68 | KDM4E (0.43) | KDM4ETDP1ALDH1A1GAAPOLB | |
| SCHEMBL4820632 | 0.68 | KDM4E (0.35) | KDM4ETDP1ALDH1A1GAAPOLB | |
| SCHEMBL14316959 | 0.67 | KDM4E (0.36) | KDM4ETDP1ALDH1A1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140142170-A1 | COMPOSITION AND METHOD FOR INFLUENCING ENERGY METABOLISM AND TREATING METABOLIC AND OTHER DISORDERS | SIRTUIN VALLEY OY (FI) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142170-A1 | COMPOSITION AND METHOD FOR INFLUENCING ENERGY METABOLISM AND TREATING METABOLIC AND OTHER DISORDERS | SIRT4, SIRT1, PFKL | KDM4E 2822/4885TDP1 4092/4885ALDH1A1 1767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.