SIRT4

NAD-dependent protein lipoamidase sirtuin-4, mitochondrial · Q9Y6E7 · SIRT4 on Sugi Atlas →

4,561 patent compounds predicted against SIRT4, 3,584 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Niacinamide (SCHEMBL460466)	1.00	1/20
Niacinamide (SCHEMBL226257)	0.96	1/20
Niacinamide (SCHEMBL508960)	0.96	1/20
Niacinamide (SCHEMBL675207)	0.96	1/20
Niacinamide (SCHEMBL1063189)	0.96	1/20
Niacinamide (SCHEMBL1220080)	0.96	1/20
Niacinamide (SCHEMBL2025759)	0.96	1/20
Niacinamide (SCHEMBL2271609)	0.96	1/20
Niacinamide (SCHEMBL472893)	0.92	1/20
Benzamide (SCHEMBL594793)	0.88	1/20
Niacinamide (SCHEMBL2745101)	0.88	1/20
Niacinamide (SCHEMBL1462628)	0.85	1/20
Niacinamide (SCHEMBL2771125)	0.85	1/20
Niacinamide (SCHEMBL3690310)	0.85	1/20
Niacinamide (SCHEMBL3718472)	0.85	1/20
Biphenyl (SCHEMBL652841)	0.81	1/20
Niacinamide (SCHEMBL810864)	0.79	1/20
Niacinamide (SCHEMBL1474936)	0.79	1/20
Niacinamide (SCHEMBL2230719)	0.79	1/20
Niacinamide (SCHEMBL2881504)	0.79	1/20

Clinical trials — most relevant to SIRT4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cardiotoxicity in Breast Cancer Patients	PHASE4	RECRUITING
The Effect of n-3 Fatty Acid Supplementation on Serum Levels, and Gene Expression of type2 Diabetes Patient	PHASE4	UNKNOWN
Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients	PHASE3	UNKNOWN
Sirtuin-NAD Activator in Alzheimer's Disease	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age	PHASE2	COMPLETED
The Safety and Efficacy of an NAD+ Boosting Product Together With a Low Carbohydrate Diet in Adults With Mild Hypertension and Eligible for Normal-standard-of-care	PHASE2	COMPLETED
Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension	PHASE2	NOT_YET_RECRUITING
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome	PHASE1/PHASE2	COMPLETED
NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals	PHASE2	RECRUITING
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults	PHASE1	RECRUITING
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors	PHASE1	RECRUITING
Project SIRT6 Activator	nan	RECRUITING
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Comparison of Cardiometabolic Markers in Individuals With Hypertriglyceridemia With Low and High Weight Loss Responses to an Energy-restricted Diet	nan	COMPLETED
How Sirtuin Levels Change During Behçet Disease	nan	UNKNOWN
Sirtuin 3 and Sirtuin 7 in Systemic Sclerosis	nan	UNKNOWN
Sirtuin1 in COVID19 Patients	nan	UNKNOWN
Study to Evaluate the Effect of Nicotinamide Riboside on Immunity	nan	COMPLETED
Impact of Nicotinamide Riboside (NR) on Kidney Function in Patients Undergoing Cardiac Surgery	nan	NOT_YET_RECRUITING
Short Interval Resveratrol Trial in Cardiovascular Surgery	nan	ACTIVE_NOT_RECRUITING
Inflammation in COPD and the Effect of Nicotinamide Riboside	nan	COMPLETED
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression	nan	COMPLETED
Effects of Protein Hydrolysate Supplement on Systemic Muscle Function Markers Following Resistance Type Exercise in Male Subjects	nan	COMPLETED
NR Supplementation and Exercise	nan	COMPLETED
Nutritional Intervention-induced Weight Loss During the Oncological Treatment of Obesity-related Breast Cancer	nan	UNKNOWN
Role of Fasted Exercise on Improving Cardiometabolic Health	nan	UNKNOWN
The Effects of Resveratrol on Sirtuins and Apoptosis Biomarkers	nan	UNKNOWN
Expression of Longevity Genes in Response to Extended Fasting	nan	COMPLETED
The Safety and Efficacy Study of RiaGev in Healthy Adults	nan	UNKNOWN
Effect of Liraglutide on Clock Genes	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a SIRT4 binder may also engage these)

Protein	Name	Similarity
Q1JQC6	—	0.998	Q1JQC6 →
Q5R6G3	—	0.994	Q5R6G3 →
Q8R216	—	0.993	Q8R216 →
Q3ZBQ0	—	0.992	Q3ZBQ0 →
F7EZ75	—	0.992	F7EZ75 →
E9GD30	—	0.987	E9GD30 →
E2RDZ6	—	0.987	E2RDZ6 →
Q20480	—	0.986	Q20480 →
Q5RBF1	—	0.986	Q5RBF1 →
F4P804	—	0.986	F4P804 →
Q94AQ6	—	0.986	Q94AQ6 →
Q20481	—	0.986	Q20481 →
F7DKV7	—	0.984	F7DKV7 →
Q6DHI5	—	0.983	Q6DHI5 →
Q68FX9	—	0.983	Q68FX9 →
A9UVV1	—	0.983	A9UVV1 →
Q7ZXP9	—	0.982	Q7ZXP9 →
Q8IRR5	—	0.982	Q8IRR5 →
Q4UZX0	—	0.982	Q4UZX0 →
Q8R104	—	0.982	Q8R104 →
Q8K370	—	0.981	Q8K370 →
Q68F47	—	0.981	Q68F47 →
Q5XHA8	—	0.981	Q5XHA8 →
Q5HZN8	—	0.981	Q5HZN8 →
SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial	0.980	landscape →
ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase	0.980	landscape →
Q2QMG2	—	0.979	Q2QMG2 →
Q9JLH6	—	0.979	Q9JLH6 →
E1BRE2	—	0.978	E1BRE2 →
Q5R557	—	0.978	Q5R557 →