Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.47 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677588 | 0.91 | LMNA (0.59) | MEN1KMT2AMAPTNR1I2LMNA | |
| SCHEMBL7089316 | 0.87 | MEN1 (0.67) | THRATHRBMEN1KMT2AMAPT | |
| SCHEMBL15728135 | 0.86 | PTPN11 (0.57) | THRATHRBPLA2G4BPTPN11 | |
| SCHEMBL30052013 | 0.82 | MAPT (0.66) | THRBMEN1KMT2AMAPTLMNA | |
| SCHEMBL1086016 | 0.82 | MAPT (0.66) | THRBMEN1KMT2AMAPTLMNA | |
| SCHEMBL7950657 | 0.82 | MTNR1A (0.51) | MEN1KMT2AMAPTNR1I2LMNA | |
| SCHEMBL4687671 | 0.82 | PARP15 (0.60) | THRATHRBMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL27585316 | 0.80 | MAPT (0.64) | THRBMEN1KMT2AMAPTLMNA | |
| SCHEMBL8337382 | 0.80 | CA12 (0.59) | THRATHRBMAPTLMNAPLA2G4B | |
| SCHEMBL1415363 | 0.80 | CA9 (0.50) | THRATHRBKMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9278940-B2 | Cyclic amines as bromodomain inhibitors | ZENITH EPIGENETICS CORP. (CA) | 2016-03-08 | — | — | US | disclosed |
| US-20150344442-A1 | CYCLIC AMINES AS BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS CORP. (CA) | 2015-12-03 | — | — | US | disclosed |
| US-9073878-B2 | Cyclic amines as bromodomain inhibitors | ZENITH EPIGENETICS CORP. (CA) | 2015-07-07 | — | — | US | disclosed |
| US-20140142102-A1 | CYCLIC AMINES AS BROMODOMAIN INHIBITORS | RVX THERAPEUTICS INC. (CA) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142102-A1 | CYCLIC AMINES AS BROMODOMAIN INHIBITORS | BRDT, BRD4, BRD3 | THRA 2700/4885THRB 1021/4885MEN1 2522/4885 |
| US-20150344442-A1 | CYCLIC AMINES AS BROMODOMAIN INHIBITORS | BRDT, BRD4, BRD3 | THRA 2700/4885THRB 1021/4885MEN1 2522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.