Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572907 | 1.00 | TSHR (0.49) | TSHRBLMNPSR1ALDH1A1LMNA | |
| SCHEMBL9319881 | 0.82 | CD69 (0.43) | TSHRALDH1A1 | |
| SCHEMBL9319877 | 0.82 | CD69 (0.43) | TSHRALDH1A1 | |
| SCHEMBL3669295 | 0.81 | AKR1C3 (0.51) | TSHRALDH1A1LMNAMAPK1PPARA | |
| SCHEMBL1572866 | 0.81 | BLM (0.62) | TSHRBLMNPSR1ALDH1A1MAPK1 | |
| SCHEMBL1572868 | 0.81 | BLM (0.62) | TSHRBLMNPSR1ALDH1A1MAPK1 | |
| SCHEMBL9191183 | 0.80 | THRB (0.39) | TSHRBLMNPSR1ALDH1A1LMNA | |
| SCHEMBL9458303 | 0.80 | THRB (0.39) | TSHRBLMNPSR1ALDH1A1LMNA | |
| SCHEMBL1573058 | 0.79 | LMNA (0.48) | TSHRBLMNPSR1ALDH1A1LMNA | |
| SCHEMBL1573057 | 0.79 | LMNA (0.48) | TSHRBLMNPSR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044067-B2 | Isoquinolines as IGF-1R inhibitors | ANALYTECON S.A. (CH) | 2011-10-25 | — | — | US | disclosed |
| EP-1931636-B1 | ISOQUINOLINES AS IGF-1R INHIBITORS | ANALYTECON SA (CH) | 2011-04-13 | — | — | EP | disclosed |
| US-5367008-A | 3-(alkoxyphenyl)benzofuran-2-ones as stabilisers | CIBA-GEIGY CORPORATION (US) | 1994-11-22 | — | — | US | disclosed |
| US-5260430-A | Stabilizers for organic materials against oxidative, thermal and light degradation | CIBA-GEIGY CORPORATION (US) | 1993-11-09 | — | — | US | disclosed |
| US-5252643-A | Heat, oxidation and light stabilizers | CIBA-GEIGY CORPORATION (US) | 1993-10-12 | — | — | US | disclosed |
| US-5216052-A | Useful for stabilization of synthetic polymers against oxidative, thermal and light-induced degradation | CIBA-GEIGY CORPORATION (US) | 1993-06-01 | — | — | US | disclosed |