Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.49 |
| ▸ | NPC1 | O15118 | 9/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SDHB | P21912 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 3/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31375610 | 0.81 | NPC1 (0.51) | RAB9ANPC1SMN1; SMN2TP53SDHB | |
| SCHEMBL28320114 | 0.81 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15723872 | 0.80 | PTPN5 (0.42) | RAB9ANPC1MEN1KMT2AKDM4E | |
| SCHEMBL17067047 | 0.80 | NOTUM (0.40) | RAB9ANPC1SMN1; SMN2TP53MEN1 | |
| SCHEMBL12266910 | 0.78 | CSF1R (0.49) | RAB9ANPC1SMN1; SMN2TP53MEN1 | |
| SCHEMBL17858736 | 0.75 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2TP53MEN1 | |
| SCHEMBL15805892 | 0.75 | RAB9A (0.60) | RAB9ANPC1SMN1; SMN2TP53MEN1 | |
| SCHEMBL17788469 | 0.73 | GRM5 (0.45) | RAB9ANPC1SMN1; SMN2TP53MEN1 | |
| SCHEMBL13921154 | 0.73 | NPC1 (0.73) | RAB9ANPC1SMN1; SMN2TP53MEN1 | |
| SCHEMBL12377809 | 0.73 | HDAC6 (0.59) | RAB9ANPC1SMN1; SMN2TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. | 2017-05-18 | — | — | US | disclosed |
| US-9540343-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20140142085-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. (US) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | RAB9A 357/4885NPC1 2/4885SMN1; SMN2 3500/4885 |
| US-20140142085-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | RAB9A 357/4885NPC1 2/4885SMN1; SMN2 3500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.