Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 2/20 | 0.48 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18854062 | 0.86 | SMN1; SMN2 (0.52) | ALDH1A1CYP3A4TSHRSMN1; SMN2KDM4E | |
| SCHEMBL14555461 | 0.86 | SMN1; SMN2 (0.55) | ALDH1A1CYP3A4TSHRSMN1; SMN2KDM4E | |
| SCHEMBL23501963 | 0.85 | ALDH1A1 (0.54) | ALDH1A1CYP3A4TSHRSMN1; SMN2KDM4E | |
| SCHEMBL15731246 | 0.80 | BRD4 (0.62) | ALDH1A1TSHRKDM4EMAPK1HTT | |
| SCHEMBL15730108 | 0.78 | DRD1 (0.54) | ALDH1A1SMN1; SMN2HTTLMNAGAA | |
| SCHEMBL15730134 | 0.77 | NPSR1 (0.49) | ALDH1A1MEN1KMT2A | |
| SCHEMBL12418061 | 0.76 | KDM4E (0.73) | ALDH1A1CYP3A4TSHRSMN1; SMN2KDM4E | |
| SCHEMBL12418055 | 0.76 | KDM4E (0.73) | ALDH1A1CYP3A4TSHRSMN1; SMN2KDM4E | |
| SCHEMBL128274 | 0.76 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TSHRSMN1; SMN2KDM4E | |
| SCHEMBL29259787 | 0.76 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TSHRSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. | 2017-05-18 | — | — | US | disclosed |
| US-9540343-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20140142085-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. (US) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | ALDH1A1 649/4885CYP3A4 247/4885TSHR 4824/4885 |
| US-20140142085-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | ALDH1A1 649/4885CYP3A4 247/4885TSHR 4824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.