SCHEMBL15733008

SCHEMBL15733008

O=C(c1c(Cl)ncnc1Cl)N(CCO)c1ccc2c(ccn2-c2ccccc2OCc2ccccc2)c1

nearest known ligand 0.49

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 7/20 0.49
RHEB Q15382 1/20 0.35
ROCK1 Q13464 1/20 0.34
PTGER1 P34995 4/20 0.33
SRD5A2 P31213 2/20 0.33
EGFR P00533 2/20 0.32
ERBB2 P04626 2/20 0.32
PPIA P62937 1/20 0.32
SRD5A1 P18405 1/20 0.32
DHODH Q02127 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15732994 0.88 DGAT1 (0.68) DGAT1RHEBROCK1PTGER1SRD5A2
SCHEMBL14136848 0.84 DGAT1 (0.59) DGAT1ROCK1DHODH
SCHEMBL20043820 0.79 RHEB (0.34) DGAT1RHEBROCK1PTGER1SRD5A2
SCHEMBL2522702 0.78 MRGPRX4 (0.43) PTGER1EGFRERBB2
SCHEMBL15733006 0.75 DGAT1 (0.55) DGAT1EGFRERBB2
SCHEMBL14136659 0.74 DGAT1 (0.56) DGAT1
SCHEMBL15733018 0.74 DGAT1 (0.62) DGAT1
SCHEMBL14136900 0.72 DGAT1 (0.59) DGAT1
SCHEMBL15522458 0.72 DGAT1 (0.82) DGAT1DHODH
SCHEMBL12208122 0.72 MRGPRX4 (0.39) DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3492474-B1 INTERMEDIATES USED IN THE PRODUCTION OF DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2021-08-11 EP disclosed
EP-3492474-B1 INTERMEDIATES USED IN THE PRODUCTION OF DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2021-08-11 EP disclosed
US-10385066-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2019-08-20 US disclosed
US-10385066-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2019-08-20 US disclosed
EP-3492474-A1 INTERMEDIATES USED IN THE PRODUCTION OF DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GlaxoSmithKline LLC (US) 2019-06-05 EP disclosed
EP-3492474-A1 INTERMEDIATES USED IN THE PRODUCTION OF DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GlaxoSmithKline LLC (US) 2019-06-05 EP disclosed
US-20190135829-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2019-05-09 US disclosed
US-20190135829-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2019-05-09 US disclosed
US-10174049-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2019-01-08 US disclosed
US-10174049-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2019-01-08 US disclosed
US-20170081342-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC 2017-03-23 US disclosed
US-20170081342-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC 2017-03-23 US disclosed
US-20170081342-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC 2017-03-23 US disclosed
US-20150322082-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2015-11-12 US disclosed
US-20150322082-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2015-11-12 US disclosed
US-20150322082-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2015-11-12 US disclosed
WO-2014081994-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-05-30 WO disclosed
US-20140148437-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-05-29 US disclosed
US-20140148437-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-05-29 US disclosed
US-20140148437-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-05-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170081342-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS DGAT1, DGAT2, LCAT DGAT1 1/4885RHEB 2574/4885ROCK1 3849/4885
US-10385066-B2 Compounds as diacylglycerol acyltransferase inhibitors DGAT1, DGAT2, LCAT DGAT1 1/4885RHEB 2261/4885ROCK1 1221/4885
US-20140148437-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS DGAT1, DGAT2, LCAT DGAT1 1/4885RHEB 2574/4885ROCK1 3849/4885
US-20150322082-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS DGAT1, DGAT2, LCAT DGAT1 1/4885RHEB 2574/4885ROCK1 3849/4885
US-20190135829-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS DGAT1, DGAT2, DLAT DGAT1 1/4885RHEB 2145/4885ROCK1 1566/4885
US-10174049-B2 Compounds as diacylglycerol acyltransferase inhibitors DGAT1, DGAT2, LCAT DGAT1 1/4885RHEB 2261/4885ROCK1 1221/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.